Human Guanine nucleotide exchange factor VAV2 (VAV2) ELISA Kit

Este producto es parte de VAV - VAV guanine nucleotide exchange factor
Human Guanine nucleotide exchange factor VAV2 (VAV2) ELISA Kit

Pida mas información

935106861

info@markelab.com

Precio

687.5€ (96 tests)

Elisa Kits VAV2

proveedor

Abbexa

reference

abx384220

Tested Applications

ELISA

reactivity

Human

status

RUO

clonality

Descripción

Human Guanine nucleotide exchange factor VAV2 (VAV2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human VAV2 concentrations in serum, plasma and other biological fluids.


Background

VAV2 is a ubiquitously expressed guanine nucleotide exchange factor (GEF) that activates Rho family GTPases, including Rac1, RhoA, and Cdc42, to regulate cytoskeletal dynamics, cell migration, and intracellular signaling pathways. Unlike VAV1, VAV2 functions in both hematopoietic and non-hematopoietic cells, where it plays roles in integrin signaling, epithelial cell polarity, and vascular development. VAV2 is activated downstream of receptor tyrosine kinases (RTKs) and integrins, linking extracellular cues to actin cytoskeleton remodeling and cell adhesion processes. Dysregulation of VAV2 is implicated in cancer progression, where it promotes cell invasion, metastasis, and epithelial-mesenchymal transition (EMT) by activating Rac1 signaling. Knockout studies reveal defects in vascular development, impaired epithelial integrity, and reduced cell migration, underscoring its role in cytoskeletal reorganization, integrin signaling, and tissue homeostasis.

Características del producto

category

ELISA Kits


immunogen target

Guanine nucleotide exchange factor VAV2 (VAV2)


reactivity

Human


test range

0.156 ng/ml - 10 ng/ml


sensitivity

< 0.094 ng/ml


assay type

Sandwich


assay data

Quantitative


detection method

Colorimetric


sample type

Serum,Plasma,Other biological fluids


size 1

96 tests


alias

VAV-2


storage

Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit


or code

VAV2


dry ice

No


note

This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.


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