Human Growth Hormone Releasing Hormone Receptor (GHRHR) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Growth Hormone Releasing Hormone Receptor (GHRHR) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx387552
tested applications
ELISA
Description
Human Growth Hormone Releasing Hormone Receptor (GHRHR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Growth Hormone Releasing Hormone Receptor (GHRHR) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Growth Hormone Releasing Hormone Receptor (GHRHR) |
| Reactivity | Human |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.312 ng/ml - 20 ng/ml |
| Sensitivity | < 0.12 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q02643 |
| Gene ID | 2692 |
| OMIM | 139191 |
| Alias | GHRHR,GRF receptor,GRFR,growth hormone-releasing factor receptor,Ghrfr,IGHD4,IGHD1B |
| Background | Elisa kits for GHRHR |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
GHRHR is a G protein-coupled receptor that binds growth hormone-releasing hormone (GHRH), regulating the synthesis and secretion of growth hormone (GH) from the anterior pituitary gland. GHRHR is primarily expressed in pituitary somatotroph cells, where its activation stimulates the cAMP/PKA and MAPK signaling pathways, leading to GH gene transcription and release. Growth hormone plays a critical role in growth, metabolism, and tissue repair by promoting the production of insulin-like growth factor-1 (IGF-1) in peripheral tissues. Mutations or dysregulation of GHRHR are associated with growth hormone deficiencies, leading to short stature, delayed growth, and metabolic imbalances. GHRHR has also been implicated in aging, where reduced GH signaling contributes to age-related declines in muscle mass and bone density. Therapeutically, GHRHR agonists are used to stimulate growth hormone production in patients with GH deficiency, while antagonists are being explored for treating acromegaly and certain cancers where GH overproduction contributes to tumor growth. GHRHR is a key target for modulating growth hormone signaling and managing growth and metabolic disorders.
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