Human Glycoprotein Ib Beta Polypeptide, Platelet (GP1BB) Protein

Background

Glycoprotein Ib platelet subunit beta (GP1BB) is a critical component of the Glycoprotein Ib-IX-V (GPIb-IX-V) complex, a receptor complex expressed on the surface of platelets. This receptor is central to platelet adhesion under conditions of high shear stress and plays a pivotal role in the initiation of platelet plug formation, particularly in arterial circulation where rapid blood flow is present. The GPIb-IX-V complex interacts with von Willebrand factor (vWF) to mediate the tethering of platelets to the site of vascular injury, marking the beginning of the hemostatic process that leads to clot formation and wound healing. GP1BB is the beta subunit of the GPIb-IX-V complex, and it is necessary for proper assembly and function of the entire receptor complex. The GP1BB protein contributes to the stability of the receptor on the platelet surface and forms part of the binding interface with other components of the GPIb-IX-V complex, including GP1BA, GPIX, and GPV.