Human Glycoprotein Ib Beta Polypeptide, Platelet (GP1BB) Protein

Este producto es parte de GP1BB - glycoprotein Ib platelet subunit beta
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1235€ (100 µg)

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935106861
info@markelab.com
name
Human Glycoprotein Ib Beta Polypeptide, Platelet (GP1BB) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691530
tested applications
SDS-PAGE

Description

Human GP1BB Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human GPIb, β polypeptide extracellular domain (NP_000398.1) (Met 1-Cys 147) with a C-terminal polyhistidine tag was expressed.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
GP1BB
Host
HEK293 cells
Origin
Human
Observed MW
Molecular Weight: 14.3 kDa
Sequence Fragment: Met1-Cys147
Tag: C-terminal His tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 97% (SDS-PAGE)
Size 1
100 µg
Form
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_000398.1
Alias
BS,CD42C,GPIBB,BDPLT1,GPIbbeta,Platelet glycoprotein Ib beta chain, GP-Ib beta,GPIb-beta,GPIbB,Antigen CD42b-beta,CD42c
Background
Protein GP1BB
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Glycoprotein Ib platelet subunit beta (GP1BB) is a critical component of the Glycoprotein Ib-IX-V (GPIb-IX-V) complex, a receptor complex expressed on the surface of platelets. This receptor is central to platelet adhesion under conditions of high shear stress and plays a pivotal role in the initiation of platelet plug formation, particularly in arterial circulation where rapid blood flow is present. The GPIb-IX-V complex interacts with von Willebrand factor (vWF) to mediate the tethering of platelets to the site of vascular injury, marking the beginning of the hemostatic process that leads to clot formation and wound healing. GP1BB is the beta subunit of the GPIb-IX-V complex, and it is necessary for proper assembly and function of the entire receptor complex. The GP1BB protein contributes to the stability of the receptor on the platelet surface and forms part of the binding interface with other components of the GPIb-IX-V complex, including GP1BA, GPIX, and GPV.
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