Human Glutamate Receptor, Metabotropic 1 (GRM1) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Glutamate Receptor, Metabotropic 1 (GRM1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx151747
tested applications
ELISA
Description
Human Glutamate Receptor, Metabotropic 1 (GRM1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Glutamate Receptor, Metabotropic 1 (GRM1) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Glutamate Receptor, Metabotropic 1 (GRM1)
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Glutamate Receptor, Metabotropic 1 (GRM1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | GRM1,GPRC1A,MGLU1,MGLUR1 PPP1R85,SCA44,SCAR13,metabotropic glutamate receptor 1,wob,glutamate receptor metabotropic 1 |
| Background | Elisa Kits for: GRM1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
GRM1, also known as mGluR1, is a G protein-coupled receptor (GPCR) that belongs to the Group I metabotropic glutamate receptors. It is widely expressed in the central nervous system (CNS), particularly in the cerebellum, hippocampus, and cortex, where it regulates excitatory neurotransmission, synaptic plasticity, and intracellular calcium signaling. GRM1 couples to Gq proteins, activating phospholipase C (PLC) and triggering the release of intracellular calcium. It plays a critical role in motor coordination, learning, and memory. Dysregulation of GRM1 has been linked to neurological disorders, including cerebellar ataxia, epilepsy, and neurodegenerative diseases such as Huntington’s disease. In cancer, GRM1 overexpression has been implicated in melanoma progression, where it enhances cell proliferation and survival. GRM1 antagonists are being explored for treating neurological disorders, chronic pain, and cancer, as targeting its signaling pathways can modulate excitatory transmission and cellular growth.
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