Human Glutamate Decarboxylase 1 (GAD1) Protein
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Description
Glutamate Decarboxylase 1 (GAD1) protein is a recombinant Human protein expressed in Insect.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Glutamate Decarboxylase 1 (GAD1) |
| Host | Insect |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Leu594 Tag: C-terminal His tag |
| Origin | Human |
| Observed MW | 68.3 kDa |
| Expression | Recombinant |
| Purity | > 92% (SDS-PAGE) |
| Size 1 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.5. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q99259-1 |
| Background | Protein GAD1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
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GAD1 antibody
This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form.
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