Human Gastric Inhibitory Polypeptide (GIP) Protein

Este producto es parte de GIP - Gastric inhibitory polypeptide ( Receptor)
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208€ (10 µg)

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935106861
info@markelab.com
name
Human Gastric Inhibitory Polypeptide (GIP) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166426
tested applications
WB, SDS-PAGE

Description

Human Gastric Inhibitory Polypeptide is a recombinant Human peptide expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Gastric Inhibitory Polypeptide (GIP)
Host
E. coli
Assay Type
Activity: Not tested
Sequence Fragment: Glu22-Arg153
Tag: N-terminal His tag
Origin
Human
Conjugation
Unconjugated
Observed MW
Calculated MW: 18.6 kDa  Observed MW (SDS-PAGE): 19 kDa
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
Availability
Shipped within 5-7 working days.
Storage
Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles.
Dry Ice
No
UniProt ID
P09681
Alias
Glucose-dependent insulinotropic polypeptide,Incretin
Background
Protein GIP
Status
RUO
Note
THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.
To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Concentration: Prior to lyophilization: 200 µg/ml

Descripción

GIP, also called glucose-dependent insulinotropic polypeptide, is a 42-amino acid hormone secreted by K-cells in the duodenum and jejunum in response to nutrient ingestion, particularly glucose, fats, and amino acids GIP acts as a critical incretin hormone that enhances glucose-dependent insulin secretion from pancreatic β-cells by activating cAMP-dependent pathways and protein kinase A signaling GIP also regulates lipid metabolism by stimulating lipoprotein lipase activity in adipose tissue, promoting triglyceride uptake and energy storage GIP further supports bone homeostasis by enhancing osteoblast function, contributing to bone formation and mineralization Dysregulation of GIP levels and signaling is associated with insulin resistance, obesity, and type 2 diabetes where its insulinotropic effects are impaired despite elevated circulating levels GIP-based therapies, including dual GIP/GLP-1 receptor agonists, have shown therapeutic potential in improving glycemic control and promoting weight loss in metabolic disorders

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