Human Gamma-Glutamylcyclotransferase (GGCT) Protein
338€ (10 µg)
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935106861
info@markelab.com
name
Human Gamma-Glutamylcyclotransferase (GGCT) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692791
tested applications
SDS-PAGE
Description
Human γ-Glutamylcyclotransferase Protein is a recombinant protein from Human produced in E. coli. Recombinant Human gamma-Glutamylcyclotransferase is produced by our E.coli expression system and the target gene encoding Met1-Leu188 is expressed with a 6His tag at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | γ-Glutamylcyclotransferase |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 23.2 kDa Sequence Fragment: Met1-Leu188 Tag: N-terminal 6 His tag Validity: The validity for this protein is 6 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM TrisHCl, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at < -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O75223 |
| Alias | GGC,GCTG,CRF21,C7orf24,Cytochrome c-releasing factor 21 |
| Background | Protein GGCT |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Gamma Glutamyl Cyclotransferase (GGCT) is an enzyme that plays a crucial role in glutathione metabolism by catalyzing the conversion of gamma-glutamyl peptides to 5-oxoproline and free amino acids. GGCT is involved in maintaining cellular redox balance and regulating glutathione homeostasis, which is essential for cellular protection against oxidative stress and detoxification processes. Dysregulation of GGCT activity has been linked to various pathological conditions, including cancer, where it is often upregulated and contributes to tumor proliferation and chemoresistance. Its role in the gamma-glutamyl cycle also makes it a potential target for therapeutic interventions in oxidative stress-related diseases.
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