Human Gamma-Glutamylcyclotransferase (GGCT) Protein
377€ (10 µg)
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935106861
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name
Human Gamma-Glutamylcyclotransferase (GGCT) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx692791
tested applications
SDS-PAGE
Description
Gamma-Glutamylcyclotransferase (GGCT) protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Gamma-Glutamylcyclotransferase (GGCT) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Leu188 Tag: N-terminal 6 His tag |
| Origin | Human |
| Observed MW | 23.2 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM TrisHCl, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles. Shelf Life: 6 months. |
| Dry Ice | No |
| UniProt ID | O75223 |
| Alias | GGC,GCTG,CRF21,C7orf24,Cytochrome c-releasing factor 21 |
| Background | Protein GGCT |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Descripción
Gamma Glutamyl Cyclotransferase (GGCT) is an enzyme that plays a crucial role in glutathione metabolism by catalyzing the conversion of gamma-glutamyl peptides to 5-oxoproline and free amino acids. GGCT is involved in maintaining cellular redox balance and regulating glutathione homeostasis, which is essential for cellular protection against oxidative stress and detoxification processes. Dysregulation of GGCT activity has been linked to various pathological conditions, including cancer, where it is often upregulated and contributes to tumor proliferation and chemoresistance. Its role in the gamma-glutamyl cycle also makes it a potential target for therapeutic interventions in oxidative stress-related diseases.
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