Human Gamma-Glutamyl Hydrolase (gGH) Protein

Pida mas información
935106861
info@markelab.com
Precio
221€ (10 µg)
Protein GGH
proveedor
Abbexareference
abx166621Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Gamma-Glutamyl Hydrolase Protein is a recombinant Human protein expressed in E. coli.
Background
Gamma-Glutamyl Hydrolase (GGH) is an enzyme involved in folate metabolism that catalyzes the hydrolysis of polyglutamated folates into monoglutamates, which are required for folate transport and cellular uptake GGH plays a key role in regulating intracellular folate levels, which are critical for DNA synthesis, repair, and methylation processes Dysregulation of GGH activity can affect cellular proliferation and is associated with conditions such as cancer, where altered folate metabolism promotes tumor growth and progression GGH expression has been linked to resistance to antifolate chemotherapeutic agents like methotrexate, as increased GGH activity reduces the retention of polyglutamated drugs, decreasing their efficacy GGH also participates in redox regulation, as folate metabolism contributes to cellular antioxidant defense pathways Studies highlight its involvement in conditions like neural tube defects and anemia due to its critical role in folate homeostasis Emerging evidence suggests that GGH activity may serve as a biomarker for cancer therapy response and other folate-related metabolic disorders
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Gamma-Glutamyl Hydrolase (gGH)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 37.3 kDa Observed MW (SDS-PAGE): 37 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg25-Asp318 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
GGH
dry ice
No
availability
Shipped within 5-7 working days.
alias
GATD10,GH,Gamma-Glu-X carboxypeptidase
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
Human GGH(Gamma-glutamyl hydrolase) ELISA Kit

proveedor
FineTestreference
EH4206reactivity
humanstatus
RUOPrecio a consultar
Ver másRecombinant Human GGH

proveedor
FineTestreference
P6332Tested Applications
Western Blot,ELISAstatus
RUOPrecio a consultar
Ver másGamma-Glutamyl Hydrolase (GGH) Antibody

proveedor
Abbexareference
abx004184Tested Applications
ELISA, WBreactivity
Human, Mousestatus
RUOclonality
PolyclonalGGH Antibody is a Rabbit Polyclonal antibody against GGH. This gene catalyzes the hydrolysis of folylpoly-gamma-glutamat...
195€ (20 µl)
Ver más