Human Gamma-Glutamyl Hydrolase (gGH) Protein
221€ (10 µg)
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935106861
info@markelab.com
name
Human Gamma-Glutamyl Hydrolase (gGH) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166621
tested applications
WB, SDS-PAGE
Description
Human Gamma-Glutamyl Hydrolase Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Gamma-Glutamyl Hydrolase (gGH) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 37.3 kDa Observed MW (SDS-PAGE): 37 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg25-Asp318 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q92820 |
| Alias | GATD10,GH,Gamma-Glu-X carboxypeptidase |
| Background | Protein GGH |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Gamma-Glutamyl Hydrolase (GGH) is an enzyme involved in folate metabolism that catalyzes the hydrolysis of polyglutamated folates into monoglutamates, which are required for folate transport and cellular uptake GGH plays a key role in regulating intracellular folate levels, which are critical for DNA synthesis, repair, and methylation processes Dysregulation of GGH activity can affect cellular proliferation and is associated with conditions such as cancer, where altered folate metabolism promotes tumor growth and progression GGH expression has been linked to resistance to antifolate chemotherapeutic agents like methotrexate, as increased GGH activity reduces the retention of polyglutamated drugs, decreasing their efficacy GGH also participates in redox regulation, as folate metabolism contributes to cellular antioxidant defense pathways Studies highlight its involvement in conditions like neural tube defects and anemia due to its critical role in folate homeostasis Emerging evidence suggests that GGH activity may serve as a biomarker for cancer therapy response and other folate-related metabolic disorders
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