Human Gamma-Glutamyl Hydrolase (GGH) Protein

Product specifications

Proteins and Peptides

Gamma-Glutamyl Hydrolase (GGH)

E. coli

Optimal dilutions/concentrations should be determined by the end user.

Human

Molecular Weight: 35.9 kDa

Concentration: 0.5 mg/ml

Sequence Fragment: 25-318 AA.

Tag: N-terminal His tag

Recombinant

> 95% (SDS-PAGE)

Purified by proprietary chromatographic techniques.

5 µg

20 µg

1 mg

Liquid

SDS-PAGE

20 mM Tris-HCl (pH 8.0), 1 mM DTT and 10% glycerol.

Shipped within 5-10 working days.

Store at 4 °C if entire vial will be used within 2-4 weeks. Store at -20 °C for long-term storage. For long-term storage, it is recommended to add a carrier protein (0.1% HAS or BSA). Avoid repeated freeze/thaw cycles.

No

Q92820

GATD10,GH,Gamma-Glu-X carboxypeptidase

Protein GGH

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Gamma-Glutamyl Hydrolase (GGH) is an enzyme involved in folate metabolism that catalyzes the hydrolysis of polyglutamated folates into monoglutamates, which are required for folate transport and cellular uptake GGH plays a key role in regulating intracellular folate levels, which are critical for DNA synthesis, repair, and methylation processes Dysregulation of GGH activity can affect cellular proliferation and is associated with conditions such as cancer, where altered folate metabolism promotes tumor growth and progression GGH expression has been linked to resistance to antifolate chemotherapeutic agents like methotrexate, as increased GGH activity reduces the retention of polyglutamated drugs, decreasing their efficacy GGH also participates in redox regulation, as folate metabolism contributes to cellular antioxidant defense pathways Studies highlight its involvement in conditions like neural tube defects and anemia due to its critical role in folate homeostasis Emerging evidence suggests that GGH activity may serve as a biomarker for cancer therapy response and other folate-related metabolic disorders

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