Human Galanin Receptor Type 2 (GALR2) ELISA Kit
715€ (96 tests)
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935106861
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name
Human Galanin Receptor Type 2 (GALR2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx524706
tested applications
ELISA
Description
Human Galanin receptor Type 2 (GALR2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Galanin receptor Type 2 (GALR2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Galanin Receptor Type 2 (GALR2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | O43603 |
| Gene ID | 8811 |
| OMIM | 603691 |
| Alias | GALR2,GALNR2,GALR-2,GAL2 receptor |
| Background | Elisa kits for GALR2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
GALR2 is a G protein-coupled receptor for the neuropeptide galanin that can couple to both Gi/o and Gq/11 proteins, allowing it to activate diverse signaling pathways. Through Gi/o coupling, GALR2 inhibits cAMP production, whereas Gq/11 coupling activates phospholipase C (PLC), leading to calcium mobilization and protein kinase C (PKC) activation. GALR2 is highly expressed in the CNS, particularly in the hypothalamus, amygdala, and dorsal root ganglia, where it regulates pain transmission, feeding behavior, and neuroprotection. GALR2 plays a pro-survival role in neurodegenerative conditions by promoting neuronal growth and survival in response to injury. In the peripheral nervous system, GALR2 mediates pain signaling, including both pro- and anti-nociceptive effects depending on tissue and receptor localization. GALR2 also promotes angiogenesis, proliferation, and survival in various cancers, including head and neck cancers, where its overexpression is associated with tumor progression. Dysregulation of GALR2 contributes to mood disorders, epilepsy, and neuropathic pain, making it a potential therapeutic target for neurodegenerative diseases, mood regulation, and cancer therapy.
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