Human GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) CLIA Kit
845€ (96 tests)
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name
Human GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx495671
tested applications
CLIA
Description
Human GABARAPL2 Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | GABA-A Receptor Associated Protein Like Protein 2 (GABARAPL2) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.061 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | ATG8,ATG8C,GATE-16,GATE16,GEF-2,GEF2 |
| Background | CLIA Kits GABARAPL2 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
GABARAPL2, another member of the GABARAP family, is essential for receptor trafficking, intracellular transport, and autophagy regulation. Like GABARAPL1, GABARAPL2 interacts with GABA-A receptors to facilitate their trafficking and proper membrane localization, maintaining synaptic inhibitory neurotransmission. It is also a core component of the autophagy machinery, functioning in autophagosome formation and lysosomal delivery of cargo proteins. GABARAPL2 interacts with autophagy-related proteins like LC3 and ATG8 to mediate selective autophagy processes, including the degradation of misfolded proteins and damaged organelles. Dysregulation of GABARAPL2 is associated with neurodegenerative disorders, such as Huntington’s and ALS, where defective autophagy contributes to protein aggregation and neuronal loss. In cancer, GABARAPL2 plays a dual role, promoting survival or apoptosis depending on cellular context, highlighting its involvement in tumor growth and chemoresistance. Its role in maintaining cellular homeostasis through autophagy and receptor regulation makes GABARAPL2 a promising therapeutic target for neurodegenerative diseases and cancer.
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