Human G-Protein Coupled Receptor 55 (GPR55) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human G-Protein Coupled Receptor 55 (GPR55) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx526039
tested applications
ELISA
Description
Human G-Protein Coupled Receptor 55 (GPR55) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human G-Protein Coupled Receptor 55 (GPR55) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | G-Protein Coupled Receptor 55 (GPR55) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 31.2 pg/ml - 2000 pg/ml |
| Sensitivity | < 14.5 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9Y2T6 |
| Gene ID | 9290 |
| OMIM | 604107 |
| Alias | GPR55,LPIR1 |
| Background | Elisa kits for GPR55 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
GPR55 is an orphan G protein-coupled receptor that has been proposed as a novel cannabinoid receptor due to its activation by endocannabinoids, including lysophosphatidylinositol (LPI), and synthetic cannabinoids. GPR55 is widely expressed in the brain, bone, gastrointestinal tract, and immune system, where it regulates diverse physiological processes. In the central nervous system, GPR55 modulates synaptic transmission, neuronal excitability, and pain perception, playing roles in neuropathic pain and neuroinflammation. In bone metabolism, GPR55 promotes osteoclast activity and bone resorption, implicating it in diseases like osteoporosis. In cancer, GPR55 is overexpressed in tumors such as breast, prostate, and pancreatic cancers, where it enhances cell proliferation, survival, and metastasis via LPI-mediated signaling. GPR55 activation triggers pathways such as RhoA/ROCK, ERK1/2, and NF-κB, influencing cell migration and inflammation. Dysregulation of GPR55 is associated with metabolic, inflammatory, and neoplastic diseases. Targeting GPR55 offers therapeutic potential for treating pain, bone disorders, and cancer, making it a key receptor in cannabinoid and lipid signaling research.
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