Human G Protein Beta Subunit Like Protein (GbL) Protein

Este producto es parte de MLST8 - G-protein beta-subunit-like
Human G Protein Beta Subunit Like Protein (GbL) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein MLST8

proveedor

Abbexa

reference

abx066709

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant G Protein Beta Subunit Like Protein (GbL) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

MTOR associated protein, LST8 homolog (MLST8), also known as mammalian lethal with SEC13 protein 8, is a core component of the mechanistic target of rapamycin (mTOR) complexes, mTORC1 and mTORC2. MLST8 is characterized by its seven WD40 repeats, forming a β-propeller structure that mediates interactions with other mTOR complex components. Within mTORC1, MLST8 contributes to substrate binding and mTOR kinase stability, enhancing its role in regulating cellular growth, metabolism, and response to nutrient availability. In mTORC2, MLST8 is crucial for the assembly and stabilization of the complex, which regulates cytoskeletal dynamics, cell survival, and metabolism. Dysregulation of MLST8 or its associated mTOR pathways has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. MLST8's functional importance makes it a potential therapeutic target for modulating mTOR activity in disease contexts.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

G Protein Beta Subunit Like Protein (GbL)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 23.5 kDa Observed MW (SDS-PAGE): 28 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp69-Trp247 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

MLST8


dry ice

No


availability

Shipped within 5-7 working days.


alias

gable,GbetaL,GBL,GBLPop3,Lst8,TORC subunit LST8,Target of rapamycin complex subunit LST8


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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