Human G Protein Beta Subunit Like Protein (GbL) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein MLST8
proveedor
Abbexareference
abx066709Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant G Protein Beta Subunit Like Protein (GbL) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
MTOR associated protein, LST8 homolog (MLST8), also known as mammalian lethal with SEC13 protein 8, is a core component of the mechanistic target of rapamycin (mTOR) complexes, mTORC1 and mTORC2. MLST8 is characterized by its seven WD40 repeats, forming a β-propeller structure that mediates interactions with other mTOR complex components. Within mTORC1, MLST8 contributes to substrate binding and mTOR kinase stability, enhancing its role in regulating cellular growth, metabolism, and response to nutrient availability. In mTORC2, MLST8 is crucial for the assembly and stabilization of the complex, which regulates cytoskeletal dynamics, cell survival, and metabolism. Dysregulation of MLST8 or its associated mTOR pathways has been linked to various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. MLST8's functional importance makes it a potential therapeutic target for modulating mTOR activity in disease contexts.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
G Protein Beta Subunit Like Protein (GbL)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 23.5 kDa Observed MW (SDS-PAGE): 28 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asp69-Trp247 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
MLST8
dry ice
No
availability
Shipped within 5-7 working days.
alias
gable,GbetaL,GBL,GBLPop3,Lst8,TORC subunit LST8,Target of rapamycin complex subunit LST8
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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