Human 3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase FUT3 (FUT3) Protein
234€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human 3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase FUT3 (FUT3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168226
tested applications
WB, SDS-PAGE
Description
3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase FUT3 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | 3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase FUT3 (FUT3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 30.4 kDa Observed MW (SDS-PAGE): 30 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Phe30-Lys259 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21217 |
| Gene ID | 2525 |
| OMIM | 111100 |
| Alias | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase FUT3,Lewis blood group,LE,Les,FT3B,CD174,FucT-III,Fucosyltransferase III |
| Background | Protein FUT3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Fucosyltransferase 3 (FUT3) is an enzyme within the glycosyltransferase family that is essential for the biosynthesis of specific carbohydrate structures on glycoproteins and glycolipids. FUT3 is responsible for catalyzing the addition of fucose, a hexose sugar, to various glycan substrates through α(1,3)- and α(1,4)-linkages, which are critical for the synthesis of the Lewis antigen family, including Lewis a (Le^a) and Lewis b (Le^b) antigens. These carbohydrate structures are integral components of cell surface glycoconjugates and play essential roles in cell-cell adhesion, recognition, and signaling. Encoded by the FUT3 gene located on chromosome 19p13.3, FUT3 is primarily expressed in epithelial tissues and leukocytes, especially in the gastrointestinal tract and other mucosal tissues. It is one of several fucosyltransferases in the human genome, with FUT3 being the most involved in the generation of Lewis antigens. The genetic variations in FUT3 are known to result in different phenotypes of Lewis antigens, which are important in blood group determination and are relevant to various diseases, including cancers and inflammatory conditions.
Related Products
Human FUT3 (Galactoside 3 (4) -L-fucosyltransferase) ELISA Kit
Ver Producto
3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase FUT3 (FUT3) Antibody
Rabbit polyclonal antibody against FUT3 protein. Immunogen region is Internal.
Ver Producto
3-Galactosyl-N-Acetylglucosaminide 4-Alpha-L-Fucosyltransferase FUT3 (FUT3) Antibody
FUT3 comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This protein is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha (1, 3) fucosyltransferase and alpha (1, 4) fucosyltransferase activities.
Ver Producto