Human Frizzled Homolog 9 (FZD9) Protein

Product specifications

Proteins and Peptides

Frizzled Homolog 9 (FZD9)

E. coli

Human

Unconjugated

Molecular Weight: Observed MW (SDS-PAGE): 30 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Leu23-Asp229
Tag: N-terminal His tag

Recombinant

> 90%

1 mg

5 mg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 1-2 months.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

FZD9,FZD3,CD349,frizzled family receptor 9

Protein FZD9

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

FZD9 is a member of the Frizzled family of G protein-coupled receptors involved in Wnt signaling, primarily through the canonical β-catenin-dependent pathway. It is highly expressed in the brain, spleen, and bone, where it plays critical roles in neuronal development, immune regulation, and bone homeostasis. In bone biology, FZD9 promotes osteoblast differentiation and mineralization, contributing to skeletal development and bone repair. Deletion or reduced expression of FZD9 is associated with bone fragility and osteoporosis, highlighting its importance in bone formation. In the central nervous system, FZD9 regulates neural connectivity, synaptic plasticity, and cognitive function, with its dysregulation linked to neurodevelopmental disorders and neurodegenerative diseases like Alzheimer’s. FZD9 also contributes to immune system function, particularly in lymphocyte development and maturation. In cancer, FZD9 expression is altered in B-cell malignancies, such as multiple myeloma, where it influences cell proliferation and survival through Wnt signaling activation. FZD9’s role in maintaining tissue homeostasis and its dysregulation in bone disease and cancer make it a potential therapeutic target for osteoporosis and hematological malignancies.

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