Human Formyl Peptide Receptor 1 (FPR1) Protein

Este producto es parte de FPR - Formyl Peptide Receptor
Product Graph
1872€ (1 mg)

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935106861
info@markelab.com
name
Human Formyl Peptide Receptor 1 (FPR1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx653458
tested applications
WB, SDS-PAGE

Description

Human Formyl Peptide Receptor 1 (FPR1) Protein is a Recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Formyl Peptide Receptor 1 (FPR1)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 39 kDa  Observed MW (SDS-PAGE): 43 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
1 mg
Size 2
5 mg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 1-2 months.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
FPR1,NFPR,FPR,formyl peptide receptor 1,fMLF-R,FPR,FMLP
Background
Protein FPR1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

FPR1 is a G protein-coupled receptor (GPCR) expressed predominantly on immune cells, such as neutrophils and macrophages, where it mediates chemotaxis and host defense responses. It recognizes formylated peptides derived from bacterial and mitochondrial proteins, triggering immune cell recruitment to infection or damaged tissues. FPR1 activation stimulates downstream signaling pathways, including PI3K/Akt, MAPK, and calcium mobilization, leading to cellular migration, degranulation, and reactive oxygen species (ROS) production. It plays a critical role in the innate immune system by detecting bacterial infections and sterile inflammation. Dysregulation of FPR1 signaling contributes to chronic inflammatory diseases, autoimmune disorders, and impaired immune responses. In cancer, FPR1 expression has been associated with tumor progression and metastasis, where it can enhance cell migration and immune evasion. FPR1 also influences tissue repair and wound healing by directing immune cells to sites of injury. Its role in immune surveillance, inflammation, and cancer progression makes it an important target for therapies aimed at modulating immune responses and improving host defense mechanisms.

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