Human Fibroblast Growth Factor Receptor 4 (FGFR4) Protein
182€ (10 µg)
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Name
Human Fibroblast Growth Factor Receptor 4 (FGFR4) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx169307
Tested Applications
SDS-PAGE, WB
Description
Human Fibroblast Growth Factor Receptor 4 (FGFR4) Protein is a recombinant protein produced in HEK293 cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Fibroblast Growth Factor Receptor 4 (FGFR4) |
| Host | HEK293 cells |
| Assay Type | Sequence Fragment: 22-369 AA. Tag: C-terminal 10 His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 40.1 kDa Observed MW (SDS-PAGE): 55 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by affinity chromatography. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE, WB |
| Buffer | PBS, containing 20% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Storage: Aliquot and store between -20 °C and -80°C. Avoid repeated freeze/thaw cycles. Stability: Stable for at least 1 month when stored between 2°C and 8°C, or for at least 12 months when stored between -20°C and -80°C. |
| Dry Ice | No |
| UniProt ID | P22455 |
| Gene ID | 2264 |
| OMIM | 134935 |
| Alias | TKF,JTK2,CD334,FGFR-4 |
| Background | Protein FGFR4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Endotoxin Level: < 0.1 ng/µg (1 IEU/µg), as measured by LAL method. |
Background
Fibroblast growth factor receptor 4 (FGFR4) FGFR4 is a member of the fibroblast growth factor receptor (FGFR) family, characterized as a transmembrane tyrosine kinase receptor that binds FGFs to regulate cell proliferation, differentiation, migration, and survival. Structurally, FGFR4 consists of an extracellular ligand-binding domain composed of three immunoglobulin-like loops, a single transmembrane domain, and an intracellular tyrosine kinase domain. FGFR4 plays essential roles in embryonic development, metabolism, and tissue homeostasis, particularly in liver, muscle, and endocrine tissues. Ligand binding activates downstream signaling cascades, including the MAPK, PI3K-AKT, and STAT pathways, which are critical for cell growth and survival. Dysregulation of FGFR4 signaling has been implicated in various cancers, such as hepatocellular carcinoma and rhabdomyosarcoma, where overexpression or mutation drives tumor growth and metastasis. Its selective expression in specific tissues and its involvement in metabolic regulation, including bile acid synthesis, highlight its specialized biological functions and potential as a therapeutic target in oncology and metabolic disorders.
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