Human Fibroblast Growth Factor Receptor 1 (FGFR1) CLIA Kit
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935106861
info@markelab.com
Precio
812.5€ (96 tests)
CLIA Kits FGFR1
proveedor
Abbexareference
abx493078Tested Applications
CLIAreactivity
Humanstatus
RUOclonality
Descripción
Human FGFR1 Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Human FGFR1 CLIA Kit is a Sandwich CLIA Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Background
Fibroblast growth factor receptor 1 (FGFR1) FGFR1 is a transmembrane tyrosine kinase receptor that binds fibroblast growth factors (FGFs), playing a critical role in cellular proliferation, differentiation, and survival. FGFR1 consists of an extracellular ligand-binding domain composed of three immunoglobulin-like loops, a single transmembrane helix, and an intracellular tyrosine kinase domain. Upon FGF binding, FGFR1 undergoes dimerization and autophosphorylation, triggering downstream signaling pathways such as the MAPK, PI3K-AKT, and PLCγ pathways. FGFR1 is essential in embryonic development, angiogenesis, and tissue repair, and its dysregulation is implicated in various cancers, including lung and breast cancer, where aberrant FGFR1 activation promotes tumor growth and survival. FGFR1 is also involved in skeletal development, and mutations in the FGFR1 gene can lead to developmental disorders such as Pfeiffer syndrome. Its widespread expression in multiple tissues highlights its diverse biological roles.
Características del producto
category
CLIA Kits
immunogen target
Fibroblast Growth Factor Receptor 1 (FGFR1)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
sensitivity
< 0.057 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Chemiluminescent
sample type
Tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
H2,H3,H4,5,CEK,FLG,BFGFR,N-SAN,CD331,FGFR-1,Proto-oncogene c-Fgr,Fms-like tyrosine kinase 2,Pfeiffer syndrome
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
FGFR1
dry ice
No
uniprot id
note
El rango y la sensibilidad pueden variar. Le recomendamos contactar con nosotros a fin de obtener la última información sobre posibles actualizaciones, que no estén representadas en este catalogo. Si necesita un rango específico, contáctenos y trataremos de ayudarle. Consulte sobre posible información que pueda ayudarle a elegir la dilución apropiada para sus muestras. Los kits CLIA están optimizados para la detección de muestras nativas, las proteínas recombinantes, pueden resultar problemáticas a causa de diferencias en la secuencia o cambios en la estructura terciaria.
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