Human Fibroblast Growth Factor 23 (FGF23) Protein

Este producto es parte de FGF23 - Fibroblast Growth Factor 23
Human Fibroblast Growth Factor 23 (FGF23) Protein

Pida mas información

935106861

info@markelab.com

Precio

234€ (10 µg)

Protein FGF23

proveedor

Abbexa

reference

abx066603

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Fibroblast Growth Factor 23 (FGF23) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

FGF23 is a phosphaturic hormone primarily secreted by osteocytes and osteoblasts in bone tissue. It regulates phosphate homeostasis and vitamin D metabolism by reducing phosphate reabsorption in the kidneys and suppressing the synthesis of 1,25-dihydroxyvitamin D. FGF23 binds to its receptor in the presence of α-Klotho, promoting phosphate excretion to maintain serum phosphate levels. Elevated FGF23 levels are associated with chronic kidney disease (CKD), where impaired renal function leads to hyperphosphatemia and secondary hyperparathyroidism. Mutations in FGF23 can cause disorders like hypophosphatemic rickets and osteomalacia, characterized by bone mineralization defects. FGF23’s role in phosphate balance and bone health makes it a key target for managing CKD and related mineral metabolism disorders.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Fibroblast Growth Factor 23 (FGF23)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 13.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala24-Val126 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

FGF23


dry ice

No


availability

Shipped within 5-12 working days.


alias

ADHR,FGFN,HYPF,HFTC2,HPDR2,PHPTC,Phosphatonin,Tumor-derived hypophosphatemia-inducing factor


NCBI accession

NP_065689.1


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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