Human Fas Associating Death Domain Containing Protein (FADD) Protein
234€ (10 µg)
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Name
Human Fas Associating Death Domain Containing Protein (FADD) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx066498
Tested Applications
WB, SDS-PAGE
Description
Human Fas Associating Death Domain Containing Protein (FADD) is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Fas Associating Death Domain Containing Protein (FADD) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Ser12-Glu206 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 25.7 kDa Observed MW (SDS-PAGE): 26 kDa |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q13158 |
| Alias | FADD,GIG3, MORT1,IMD90 |
| Background | Protein FADD |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in ddH2O to a concentration up to 0.5 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 400 µg/ml |
Background
FADD is an adaptor protein critical for death receptor-mediated apoptosis and immune signaling. It binds to death receptors like FAS (CD95), TNFR1, and TRAIL-R through its death domain (DD), facilitating the recruitment of caspase-8 to form the death-inducing signaling complex (DISC). This activates caspase cascades, leading to programmed cell death. FADD also participates in necroptosis, a caspase-independent cell death pathway, by interacting with receptor-interacting proteins (RIPK1 and RIPK3). Beyond cell death, FADD regulates T-cell proliferation, innate immune signaling, and NF-κB activation. Dysregulation of FADD is implicated in cancers, autoimmune diseases, and viral infections, where it affects apoptosis resistance and inflammation. Knockout studies reveal its essential role in embryonic development, immune homeostasis, and T-cell activation, emphasizing its dual function in cell survival and death signaling.
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