Human Fas Associating Death Domain Containing Protein (FADD) Protein
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935106861
info@markelab.com
Precio
234€ (10 µg)
Protein FADD
proveedor
Abbexareference
abx066498Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Fas Associating Death Domain Containing Protein (FADD) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
FADD is an adaptor protein critical for death receptor-mediated apoptosis and immune signaling. It binds to death receptors like FAS (CD95), TNFR1, and TRAIL-R through its death domain (DD), facilitating the recruitment of caspase-8 to form the death-inducing signaling complex (DISC). This activates caspase cascades, leading to programmed cell death. FADD also participates in necroptosis, a caspase-independent cell death pathway, by interacting with receptor-interacting proteins (RIPK1 and RIPK3). Beyond cell death, FADD regulates T-cell proliferation, innate immune signaling, and NF-κB activation. Dysregulation of FADD is implicated in cancers, autoimmune diseases, and viral infections, where it affects apoptosis resistance and inflammation. Knockout studies reveal its essential role in embryonic development, immune homeostasis, and T-cell activation, emphasizing its dual function in cell survival and death signaling.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Fas Associating Death Domain Containing Protein (FADD)
host
E. coli
conjugation
Unconjugated
form
Lyophilized Reconstitute in ddH2O to a concentration up to 0.5 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 25.7 kDa Observed MW (SDS-PAGE): 26 kDa Concentration: Prior to lyophilization: 400 µg/ml Sequence Fragment: Ser12-Glu206 Tag: N-terminal His tag
expression
Recombinant
purity
> 90%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
FADD
dry ice
No
availability
Shipped within 5-7 working days.
alias
FADD,GIG3, MORT1,IMD90
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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