Human FAS-Associated Death Domain Protein (FADD) Cell ELISA Kit
513.5€ (96 tests)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Human FAS-Associated Death Domain Protein (FADD) Cell ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx595216
Tested Applications
ELISA
Description
FADD Cell ELISA Kit is a cell-based ELISA Kit. Cells to be assayed should be seeded onto a clear flat bottom 96 well plate, using poly-L-lysine for non-adherent cells. Cells should be grown to 75-90% confluence and treated prior to carrying out the ELISA.
Documentos del producto
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | FAS-Associated Death Domain Protein (FADD) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Tested Applications | ELISA |
| Availability | Shipped within 1-2 weeks. |
| Storage | Shipped at 4°C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q13158 |
| Gene ID | 8772 |
| OMIM | 602457 |
| Alias | FADD,GIG3, MORT1,IMD90 |
| Background | Elisa Kits for: FADD |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Background
FADD is an adaptor protein critical for death receptor-mediated apoptosis and immune signaling. It binds to death receptors like FAS (CD95), TNFR1, and TRAIL-R through its death domain (DD), facilitating the recruitment of caspase-8 to form the death-inducing signaling complex (DISC). This activates caspase cascades, leading to programmed cell death. FADD also participates in necroptosis, a caspase-independent cell death pathway, by interacting with receptor-interacting proteins (RIPK1 and RIPK3). Beyond cell death, FADD regulates T-cell proliferation, innate immune signaling, and NF-κB activation. Dysregulation of FADD is implicated in cancers, autoimmune diseases, and viral infections, where it affects apoptosis resistance and inflammation. Knockout studies reveal its essential role in embryonic development, immune homeostasis, and T-cell activation, emphasizing its dual function in cell survival and death signaling.
Productos relacionados
FAS-Associated Death Domain Protein (FADD) Antibody
FADD Antibody is a Rabbit Polyclonal antibody against FADD. The protein encoded by this gene is an adaptor molecule that…
Ver producto
FADD (Phospho-Ser191) Antibody
Rabbit polyclonal antibody against FADD protein. Immunogen region is C-terminal. Specificity is as follows for the react…
Ver producto
Fas (TNFRSF6)-Associated Via Death Domain (FADD) Antibody
Rabbit polyclonal antibody against FADD protein. Immunogen region is C-terminal.…
Ver producto