Human Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3 (EIF2AK3) Protein
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Description
Human Eukaryotic Translation Initiation Factor 2 alpha Kinase 3 (EIF2AK3) Protein is a Human recombinant protein produced in E. coli.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Eukaryotic Translation Initiation Factor 2 Alpha Kinase 3 (EIF2AK3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Sequence Fragment: 563-1115 AA. Tag: N-terminal 10 His tag and C-terminal Myc tag Validity: 6 months in liquid form, or 12 months in lyophilized form. |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 50 µg |
| Size 2 | 200 µg |
| Size 3 | 500 µg |
| Size 4 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | Tris-based buffer, 50% glycerol. |
| Availability | Shipped within 2-3 months. |
| Storage | Store at 4 °C for up to one week. For long term storage, store at -20 or -80 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q9NZJ5 |
| Gene ID | 9451 |
| OMIM | 226980 |
| Background | Protein EIF2AK3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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EIF2AK3 antibody
Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2(eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response(UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response(UPR)-induced G1 growth arrest due to the loss of cyclin-D1(CCND1). Involved in control of mitochondrial morphology and function.
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