Human Estrogen Receptor Alpha (ESR1) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Human Estrogen Receptor Alpha Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Estrogen Receptor Alpha (ESR1) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 33.4 kDa Observed MW (SDS-PAGE): 33 kDa Concentration: Prior to lyophilization: 250 µg/ml Sequence Fragment: Ser178-Met438 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P03372 |
| Alias | ER,ESR,Era; ESRA,ESTRR,NR3A1,Nuclear receptor subfamily 3 group A member 1,Estradiol receptor |
| Background | Protein ESR1 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Estrogen receptor 1 (ESR1), also known as ERα, is a nuclear receptor that mediates the effects of estrogen, a key hormone in regulating the female reproductive system and other physiological processes ESR1 is expressed in a variety of tissues, including the breast, uterus, brain, and bones, where it regulates gene expression related to reproductive health, bone metabolism, and brain function Upon binding to estrogen, ESR1 undergoes a conformational change, allowing it to bind to estrogen response elements (EREs) on target genes and modulate their expression This activation regulates processes such as cell proliferation, differentiation, and apoptosis, and it is essential for the normal development of the reproductive organs and the maintenance of bone density Dysregulation of ESR1 has been linked to various diseases, particularly hormone receptor-positive breast cancer, where overactivation of ESR1 signaling promotes tumor cell growth and survival ESR1 is also a therapeutic target in breast cancer, with drugs like selective estrogen receptor modulators (SERMs) used to block or modulate its activity in cancer treatment
Related Products
Rat Esr1(Estrogen receptor) ELISA Kit
Ver Producto
Recombinant Human ESR1
Ver Producto
ESR1 (pS118) Antibody
ESR1 (pS118) Antibody is a Rabbit Polyclonal antibody against ESR1 (pS118). This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative splicing results in several transcript variants, which differ in their 5' UTRs and use different promoters.
Ver Producto