Human Endoglin / CD105 (ENG) Protein

Este producto es parte de ENG - endoglin
Human Endoglin / CD105 (ENG) Protein

Pida mas información

935106861

info@markelab.com

Precio

208€ (10 µg)

Protein ENG

proveedor

Abbexa

reference

abx652145

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Endoglin / CD105 (ENG) Protein is a Recombinant Protein produced in E.coli using Prokaryotic expression.


Background

Endoglin, encoded by the ENG gene, is a key transmembrane glycoprotein in the TGF-β (transforming growth factor-beta) receptor complex, with significant roles in vascular development and endothelial cell biology. Also known as CD105, endoglin is crucial in angiogenesis and vascular homeostasis. It is prominently expressed on the surface of endothelial cells, especially in active angiogenic areas, as well as in other cell types like smooth muscle cells and some immune cells. Endoglin regulates cellular responses to TGF-β signaling, particularly within endothelial cells, which is essential for their proliferation, migration, and survival. Mutations in the ENG gene are linked to hereditary hemorrhagic telangiectasia type 1 (HHT1), a genetic disorder characterized by abnormal blood vessel formation, causing arteriovenous malformations, frequent nosebleeds, and other bleeding-related symptoms. Endoglin also plays a prominent role in cancer biology, where it can act as a biomarker for tumor angiogenesis. Its dual role in promoting normal vascular health and contributing to disease makes it an essential molecule in vascular biology research.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Endoglin / CD105 (ENG)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 14.0 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr336-Phe450 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ENG


dry ice

No


availability

Shipped within 5-12 working days.


alias

END,HHT1,ORW1,CD105


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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