Human Endoglin / CD105 (ENG) Protein
234€ (2 µg)
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935106861
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name
Human Endoglin / CD105 (ENG) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx263135
tested applications
SDS-PAGE
Description
Endoglin / CD105 (ENG) is a Recombinant Human Protein produed in sf9 Insect cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Endoglin / CD105 (ENG) |
| Host | Insect |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 1 mg/ml |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE and RP-HPLC) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 100 µg |
| Form | Lyophilized Reconstitute the lyophilized CD105 in sterile PBS not less than 100µg/ml, which can then be further diluted to other aqueous solutions. |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Storage | Stable at room temperature for up to 3 weeks. It is recommended to store this product desiccated at or below -18 °C. After reconstitution, store at 4 °C for short-term storage (up to 7 days) or below -18 °C for long-term storage. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P17813 |
| Alias | END,HHT1,ORW1,CD105 |
| Background | Protein ENG |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Endoglin, encoded by the ENG gene, is a key transmembrane glycoprotein in the TGF-β (transforming growth factor-beta) receptor complex, with significant roles in vascular development and endothelial cell biology. Also known as CD105, endoglin is crucial in angiogenesis and vascular homeostasis. It is prominently expressed on the surface of endothelial cells, especially in active angiogenic areas, as well as in other cell types like smooth muscle cells and some immune cells. Endoglin regulates cellular responses to TGF-β signaling, particularly within endothelial cells, which is essential for their proliferation, migration, and survival. Mutations in the ENG gene are linked to hereditary hemorrhagic telangiectasia type 1 (HHT1), a genetic disorder characterized by abnormal blood vessel formation, causing arteriovenous malformations, frequent nosebleeds, and other bleeding-related symptoms. Endoglin also plays a prominent role in cancer biology, where it can act as a biomarker for tumor angiogenesis. Its dual role in promoting normal vascular health and contributing to disease makes it an essential molecule in vascular biology research.
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This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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