Human Endoglin / CD105 (ENG) Protein
221€ (10 µg)
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name
Human Endoglin / CD105 (ENG) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx066401
tested applications
WB, SDS-PAGE
Description
Human Endoglin / CD105 (ENG) Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Endoglin / CD105 (ENG) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Thr336-Phe450 Tag: N-terminal His tag |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Calculated MW: 13.8 kDa Observed MW (SDS-PAGE): 16 kDa |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01%Sarcosyl, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store lyophilized form at 2-8°C for up to 1 month. For longer periods, store lyophilized or liquid at -80°C. Avoid repeated freeze–thaw cycles. |
| Dry Ice | No |
| UniProt ID | P17813 |
| Alias | END,HHT1,ORW1,CD105 |
| Background | Protein ENG |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. Concentration: Prior to lyophilization: 200 µg/ml |
Descripción
Endoglin, encoded by the ENG gene, is a key transmembrane glycoprotein in the TGF-β (transforming growth factor-beta) receptor complex, with significant roles in vascular development and endothelial cell biology. Also known as CD105, endoglin is crucial in angiogenesis and vascular homeostasis. It is prominently expressed on the surface of endothelial cells, especially in active angiogenic areas, as well as in other cell types like smooth muscle cells and some immune cells. Endoglin regulates cellular responses to TGF-β signaling, particularly within endothelial cells, which is essential for their proliferation, migration, and survival. Mutations in the ENG gene are linked to hereditary hemorrhagic telangiectasia type 1 (HHT1), a genetic disorder characterized by abnormal blood vessel formation, causing arteriovenous malformations, frequent nosebleeds, and other bleeding-related symptoms. Endoglin also plays a prominent role in cancer biology, where it can act as a biomarker for tumor angiogenesis. Its dual role in promoting normal vascular health and contributing to disease makes it an essential molecule in vascular biology research.
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This gene encodes a homodimeric transmembrane protein which is a major glycoprotein of the vascular endothelium. This protein is a component of the transforming growth factor beta receptor complex and it binds to the beta1 and beta3 peptides with high affinity. Mutations in this gene cause hereditary hemorrhagic telangiectasia, also known as Osler-Rendu-Weber syndrome 1, an autosomal dominant multisystemic vascular dysplasia. This gene may also be involved in preeclampsia and several types of cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
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