Human Endoglin / CD105 (ENG) Protein

Pida mas información
935106861
info@markelab.com
Precio
221€ (10 µg)
Protein ENG
proveedor
Abbexareference
abx066401Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Endoglin / CD105 (ENG) Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
Endoglin, encoded by the ENG gene, is a key transmembrane glycoprotein in the TGF-β (transforming growth factor-beta) receptor complex, with significant roles in vascular development and endothelial cell biology. Also known as CD105, endoglin is crucial in angiogenesis and vascular homeostasis. It is prominently expressed on the surface of endothelial cells, especially in active angiogenic areas, as well as in other cell types like smooth muscle cells and some immune cells. Endoglin regulates cellular responses to TGF-β signaling, particularly within endothelial cells, which is essential for their proliferation, migration, and survival. Mutations in the ENG gene are linked to hereditary hemorrhagic telangiectasia type 1 (HHT1), a genetic disorder characterized by abnormal blood vessel formation, causing arteriovenous malformations, frequent nosebleeds, and other bleeding-related symptoms. Endoglin also plays a prominent role in cancer biology, where it can act as a biomarker for tumor angiogenesis. Its dual role in promoting normal vascular health and contributing to disease makes it an essential molecule in vascular biology research.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Endoglin / CD105 (ENG)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 13.8 kDa Observed MW (SDS-PAGE): 16 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Thr336-Phe450 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01%Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ENG
dry ice
No
availability
Shipped within 5-7 working days.
alias
END,HHT1,ORW1,CD105
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
Human ENG(Endoglin) ELISA Kit

proveedor
FineTestreference
EH0071reactivity
humanstatus
RUOPrecio a consultar
Ver másMouse Eng(Endoglin) ELISA Kit

proveedor
FineTestreference
EM0280reactivity
mousestatus
RUOPrecio a consultar
Ver másRat ENG(Endoglin) ELISA Kit

proveedor
FineTestreference
ER1850reactivity
ratstatus
RUOPrecio a consultar
Ver más