Human Endoglin / CD105 (ENG) CLIA Kit

Este producto es parte de ENG - endoglin
Human Endoglin / CD105 (ENG) CLIA Kit

Pida mas información

935106861

info@markelab.com

Precio

845€ (96 tests)

CLIA Kits ENG

proveedor

Abbexa

reference

abx492290

Tested Applications

CLIA

reactivity

Human

status

RUO

clonality

Descripción

Human Endoglin / CD105 (ENG) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.

Background

Endoglin, encoded by the ENG gene, is a key transmembrane glycoprotein in the TGF-β (transforming growth factor-beta) receptor complex, with significant roles in vascular development and endothelial cell biology. Also known as CD105, endoglin is crucial in angiogenesis and vascular homeostasis. It is prominently expressed on the surface of endothelial cells, especially in active angiogenic areas, as well as in other cell types like smooth muscle cells and some immune cells. Endoglin regulates cellular responses to TGF-β signaling, particularly within endothelial cells, which is essential for their proliferation, migration, and survival. Mutations in the ENG gene are linked to hereditary hemorrhagic telangiectasia type 1 (HHT1), a genetic disorder characterized by abnormal blood vessel formation, causing arteriovenous malformations, frequent nosebleeds, and other bleeding-related symptoms. Endoglin also plays a prominent role in cancer biology, where it can act as a biomarker for tumor angiogenesis. Its dual role in promoting normal vascular health and contributing to disease makes it an essential molecule in vascular biology research.

Características del producto

category

CLIA Kits

immunogen target

Endoglin / CD105 (ENG)

reactivity

Human

test range

0.156 ng/ml - 10 ng/ml

sensitivity

< 0.062 ng/ml

assay type

Sandwich

assay data

Quantitative

form

Lyophilized

detection method

Chemiluminescent

sample type

Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids.

size 1

96 tests

size 2

5 × 96 tests

size 3

10 × 96 tests

alias

END,HHT1,ORW1,CD105

storage

Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

or code

ENG

dry ice

No

uniprot id

https://www.uniprot.org/uniprotkb/P17813

gene id

https://www.ncbi.nlm.nih.gov/gene/2022

note

The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Quizá le pueda interesar

Human ENG(Endoglin) ELISA Kit

Human ENG(Endoglin) ELISA Kit

proveedor

FineTest

reference

EH0071

reactivity

human

status

RUO

Precio a consultar

Ver más

Mouse Eng(Endoglin) ELISA Kit

Mouse Eng(Endoglin) ELISA Kit

proveedor

FineTest

reference

EM0280

reactivity

mouse

status

RUO

Precio a consultar

Ver más

Rat ENG(Endoglin) ELISA Kit

Rat ENG(Endoglin) ELISA Kit

proveedor

FineTest

reference

ER1850

reactivity

rat

status

RUO

Precio a consultar

Ver más