Human E3 Ubiquitin-Protein Ligase CBL-C / CBL-3 (CBLC) Protein
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Description
Human Cbl-c Protein is a recombinant protein from Human produced in Baculovirus-Insect Cells. A DNA sequence encoding the human CBLC (AAH28915.1) (Met1-Ala474) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Cbl-c |
| Host | Insect |
| Origin | Human |
| Observed MW | Molecular Weight: 80.2 kDa Sequence Fragment: Met1-Ala474 Tag: N-terminal His tag and GST tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 20mM Tris, 500mM Nacl, 10% glycerol, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | AAH28915.1 |
| Alias | CBL-C,CBLC,RNF57,CBL-SL,CBL-3 |
| Background | Protein CBLC |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CBLC is a member of the CBL family of ubiquitin ligases. It functions similarly to CBL and CBLB in modulating receptor signaling through ubiquitination. CBLC is involved in regulating the endocytosis and degradation of RTKs by promoting the ubiquitination of specific substrates. This regulation is essential in controlling the intensity and duration of signaling pathways that govern cell growth and differentiation. CBLC also plays a role in immune system signaling, where its activity contributes to the fine-tuning of immune cell activation. Like other CBL family members, CBLC is implicated in various diseases, including cancer and immune disorders, due to its role in regulating key cellular processes.
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