Human E3 Ubiquitin-Protein Ligase CBL-C / CBL-3 (CBLC) Protein
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935106861
info@markelab.com
Precio
1001€ (100 µg)
Protein CBLC
proveedor
Abbexareference
abx693482Tested Applications
SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Cbl-c Protein is a recombinant protein from Human produced in Baculovirus-Insect Cells. A DNA sequence encoding the human CBLC (AAH28915.1) (Met1-Ala474) was expressed with the N-terminal polyhistidine-tagged GST tag at the N-terminus.
Background
CBLC is a member of the CBL family of ubiquitin ligases. It functions similarly to CBL and CBLB in modulating receptor signaling through ubiquitination. CBLC is involved in regulating the endocytosis and degradation of RTKs by promoting the ubiquitination of specific substrates. This regulation is essential in controlling the intensity and duration of signaling pathways that govern cell growth and differentiation. CBLC also plays a role in immune system signaling, where its activity contributes to the fine-tuning of immune cell activation. Like other CBL family members, CBLC is implicated in various diseases, including cancer and immune disorders, due to its role in regulating key cellular processes.
Características del producto
category
Proteins and Peptides
origin
Human
host
Insect
immunogen target
Cbl-c
host
Insect
form
tested applications
SDS-PAGE
size 1
100 µg
observerd MW
Molecular Weight: 80.2 kDa Sequence Fragment: Met1-Ala474 Tag: N-terminal His tag and GST tag Validity: The validity for this protein is 12 months.
expression
Recombinant
purity
> 95% (SDS-PAGE)
buffer
Lyophilized from sterile 20mM Tris, 500mM Nacl, 10% glycerol, pH 8.0.
storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
or code
CBLC
dry ice
No
availability
Shipped within 5-15 working days.
alias
CBL-C,CBLC,RNF57,CBL-SL,CBL-3
NCBI accession
AAH28915.1
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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