Human Dopamine Receptor D2 (DRD2) Protein
247€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
935106861
info@markelab.com
name
Human Dopamine Receptor D2 (DRD2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652124
tested applications
WB, SDS-PAGE
Description
Human Dopamine Receptor D2 (DRD2) Protein is a Recombinant Human protein expressed in E.coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Dopamine Receptor D2 (DRD2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 24.9 kDa Observed MW (SDS-PAGE): 26 kDa Concentration: Prior to lyophilization: 70 µg/ml Sequence Fragment: Val200-Ile384 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl and 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P14416 |
| Gene ID | 1813 |
| Alias | DRD2,D2A,D2B,dopamine D2 receptor,dopamine receptor 2,D2 receptor,D2R,D2DR |
| Background | Protein DRD2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
DRD2 is a G protein-coupled receptor belonging to the D2-like receptor family and is highly expressed in the striatum, substantia nigra, and hypothalamus, where it regulates motor control, reward processing, and endocrine function. DRD2 primarily couples to Gi/o proteins, which inhibit adenylate cyclase, reducing cyclic AMP (cAMP) levels and modulating downstream signaling pathways. It exists in two isoforms: the short form (D2S), which functions presynaptically to inhibit dopamine release, and the long form (D2L), which mediates postsynaptic signaling. DRD2 plays a key role in motor control, and its dysfunction is closely linked to Parkinson’s disease, where loss of dopaminergic neurons leads to motor deficits. In neuropsychiatric disorders, DRD2 dysregulation contributes to schizophrenia, bipolar disorder, and drug addiction, where abnormal dopamine signaling disrupts cognition, behavior, and reward mechanisms. Antipsychotic drugs primarily target DRD2 to alleviate symptoms of psychosis by blocking receptor activity. DRD2 also regulates prolactin secretion from the pituitary gland, and its antagonism can cause hyperprolactinemia. Beyond the CNS, DRD2 influences cardiovascular and gastrointestinal function. Given its central role in motor control, reward signaling, and neuropsychiatric disorders, DRD2 remains a critical therapeutic target for Parkinson’s disease, schizophrenia, and substance abuse.
Related Products
Human D2R/DRD2 (Dopamine Receptor D2) ELISA Kit
Ver Producto
DRD2 antibody
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase.
Ver Producto