Human Docking protein 2 (DOK2) ELISA Kit

Pida mas información
935106861
info@markelab.com
Precio
715€ (96 tests)
Elisa kits for DOK2
proveedor
Abbexareference
abx555864Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Docking protein 2 (DOK2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DOK2 concentrations in serum, plasma and other biological fluids.
Background
Docking protein 2 (DOK2) is another member of the DOK family, predominantly expressed in hematopoietic cells. Like DOK1, DOK2 functions as a negative regulator of tyrosine kinase-mediated signaling pathways. It is essential for modulating immune cell activation, particularly in T cells, B cells, and macrophages. DOK2 interacts with various signaling proteins, such as SH2-containing phosphatase 2 (SHP2) and Ras-GAP, to dampen downstream signaling cascades. This regulation is vital for maintaining immune homeostasis and preventing overactivation that could lead to autoimmunity. DOK2 has also been identified as a tumor suppressor, with its inactivation or downregulation contributing to the pathogenesis of leukemias and other cancers. Its roles in both immune regulation and oncogenesis make it a key target for therapeutic research.
Características del producto
category
ELISA Kits
immunogen target
Docking protein 2 (DOK2)
reactivity
Human
test range
78 pg/ml - 5000 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma and other biological fluids.
size 1
96 tests
alias
Downstream of tyrosine kinase 2,p56DOK,p56dok-2
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
DOK2
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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