Human DmX-Like Protein 2 (DMXL2) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human DmX-Like Protein 2 (DMXL2) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx386917
tested applications
ELISA
Description
Human DmX-Like Protein 2 (DMXL2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DMXL2 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | DmX-Like Protein 2 (DMXL2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8TDJ6 |
| Gene ID | 23312 |
| OMIM | 612186 |
| Alias | RC3,DEE81,PEPNS,DFNA71,EIEE81,Rabconnectin-3,DmX-like protein 2 |
| Background | Elisa kits for DMXL2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Dmx like 2 (DMXL2), also known as rabconnectin-3α, is a WD40-repeat protein involved in vesicle trafficking and signaling, with critical roles in neurotransmitter release, autophagy, and lysosomal function. DMXL2 functions as a scaffold protein, mediating interactions between Rab GTPases and their effectors, particularly in vesicle docking and fusion. It is heavily involved in the regulation of vesicular trafficking pathways in neurons and endocrine cells, where it modulates the release of neurotransmitters and hormones. DMXL2 is also linked to the regulation of the vacuolar-type H+-ATPase (v-ATPase), which is essential for lysosomal acidification and autophagic degradation processes. Its expression is highest in neural, endocrine, and metabolic tissues, reflecting its involvement in processes like synaptic signaling and energy homeostasis. Dysregulation of DMXL2 has been associated with neurodevelopmental disorders, diabetes, and lysosomal storage diseases, where defects in vesicular and lysosomal trafficking contribute to disease pathology. Its diverse roles in vesicle-mediated transport make DMXL2 a key regulator of intracellular dynamics and signaling pathways.
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