Human Dipeptidyl Peptidase 4 / CD26 (DPP4) Enzyme

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Especificaciones del producto

Proteins and Peptides

Dipeptidyl Peptidase 4 / CD26 (DPP4)

Insect

Biological Activity: > 200 Units/mg
One unit will hydrolyze 1 µmol of p-nitroaniline per minute at pH 8.0 at 37 °C using 1 mM of Gly-Pro p-nitroanilde as the substrate.
Sequence Fragment: 39-766 AA
Tag: C-terminal His tag

Optimal dilutions/concentrations should be determined by the end user.

Human

85.4 kDa

Recombinant

> 95% (SDS-PAGE)

Purified by conventional chromatography techniques.

2 µg

10 µg

1 mg

Liquid

SDS-PAGE

20 mM Tris-HCl buffer, pH 8, 100 mM NaCl, 1 mM EDTA and 10% glycerol.

Shipped within 5-10 working days.

Store at 4°C if the entire vial will be used within 4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles.

No

P27487

CD26,ADABP,ADCP2,DPPIV,TP103,Dipeptidyl peptidase 4,Adenosine deaminase complexing protein 2,ADCP-2,Dipeptidyl peptidase IV,T-cell activation antigen CD26

Protein DPP4

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Background

Dipeptidyl peptidase 4 (DPP4), also known as CD26, is a transmembrane glycoprotein and serine protease that plays a significant role in regulating glucose metabolism, immune function, and cell signaling. It is expressed on the surface of various cell types, including epithelial cells, endothelial cells, and immune cells such as T cells and B cells. DPP4 is widely known for its role in glucose homeostasis through its enzymatic activity, where it deactivates incretin hormones like glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). These hormones promote insulin release in response to meals, and their inactivation by DPP4 reduces insulin secretion, thereby impacting blood sugar levels. Beyond its metabolic functions, DPP4 also participates in various immune regulatory pathways. As CD26, it is involved in T-cell activation and co-stimulation. DPP4 is linked to inflammatory processes and certain cancers, particularly due to its enzymatic activity and role in regulating immune responses. Additionally, the soluble form of DPP4 (sDPP4), which circulates in the plasma, plays a role in systemic metabolic and immune regulation.

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