Human DENN domain-containing protein 4C (DENND4C) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human DENN domain-containing protein 4C (DENND4C) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx510102
tested applications
ELISA
Description
Human DENN domain-containing protein 4C (DENND4C) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DENN domain-containing protein 4C (DENND4C) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | DENN domain-containing protein 4C (DENND4C) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q5VZ89 |
| Alias | C9orf55,C9orf55B |
| Background | Elisa kits for DENND4C |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
DENN domain containing 4C (DENND4C) is a guanine nucleotide exchange factor (GEF) that specifically activates Rab10, a small GTPase involved in vesicular trafficking, endosomal recycling, and membrane transport. DENND4C facilitates the GDP-to-GTP exchange on Rab10, enabling the active transport of cargo-containing vesicles to the plasma membrane or other intracellular compartments. It plays a significant role in regulating glucose transporter (GLUT4) recycling in adipocytes, which is essential for glucose uptake and cellular metabolism. DENND4C is also implicated in polarized transport in epithelial cells, ensuring proper protein and lipid distribution within specialized membrane domains. It is broadly expressed but shows elevated activity in metabolically active tissues such as muscle and adipose tissue. Dysregulation of DENND4C has been linked to metabolic disorders, including obesity and insulin resistance, where defective GLUT4 trafficking contributes to impaired glucose homeostasis. Its function in vesicle dynamics underscores its importance in cellular signaling, metabolism, and energy regulation.
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