Human DENN Domain Containing Protein 1A (DENND1A) ELISA Kit
715€ (96 tests)
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935106861
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name
Human DENN Domain Containing Protein 1A (DENND1A) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx386855
tested applications
ELISA
Description
Human DENN Domain Containing Protein 1A (DENND1A) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human DENND1A concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | DENN Domain Containing Protein 1A (DENND1A) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q8TEH3 |
| Gene ID | 57706 |
| OMIM | 613633 |
| Alias | FAM31A,KIAA1608,Connecdenn 1,Connecdenn |
| Background | Elisa kits for DENND1A |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
DENN domain containing 1A (DENND1A) is a critical guanine nucleotide exchange factor (GEF) for Rab35, a small GTPase involved in endosomal trafficking and membrane recycling. DENND1A regulates the cycling of Rab35 between its GDP-bound inactive form and GTP-bound active state, promoting endosomal sorting and exocytosis. It is particularly important in processes like cytokinesis, where Rab35 facilitates the trafficking of vesicles required for the separation of daughter cells. DENND1A is also implicated in recycling plasma membrane components, such as receptors and transporters, ensuring proper cellular signaling and nutrient uptake. Dysregulation of DENND1A has been linked to pathological conditions, including polycystic ovary syndrome (PCOS), where it may contribute to hormonal imbalances and altered cellular signaling. Its tissue-specific expression, particularly in reproductive and endocrine tissues, underscores its specialized roles in vesicle trafficking and cellular function.
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