Human Dedicator Of Cytokinesis 2 (DOCK2) Protein

Este producto es parte de DOCK - Dedicator of Cytokinesis
Human Dedicator Of Cytokinesis 2 (DOCK2) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein DOCK2

proveedor

Abbexa

reference

abx166509

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Dedicator Of Cytokinesis 2 Protein is a recombinant Human protein expressed in E. coli.


Background

DOCK2 is a hematopoietic-specific GEF expressed in leukocytes, activating Rac1/Rac2 to control chemotaxis and immune cell migration. It regulates lymphocyte development, T cell activation, and neutrophil responses to chemokines like CXCL12. DOCK2 interacts with ELMO1 to mediate actin polymerization, essential for leukocyte motility and immune responses. Dysregulation causes defects in lymphocyte trafficking and inflammation. In infections and cancer, DOCK2 can promote or suppress disease progression. Its activity depends on membrane lipids like PIP3 and phosphorylation. Knockout models show immunodeficiency and impaired immune surveillance, emphasizing DOCK2’s role in immunity.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Dedicator Of Cytokinesis 2 (DOCK2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 31.7 kDa Observed MW (SDS-PAGE): 32 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile390-Glu635 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

DOCK2


dry ice

No


availability

Shipped within 5-7 working days.


alias

DOCK2, IMD40, Dock2, dedicator of cytokinesis 2


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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