Human Dedicator Of Cytokinesis 2 (DOCK2) Protein

Este producto es parte de DOCK - Dedicator of Cytokinesis
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221€ (10 µg)

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935106861
info@markelab.com
name
Human Dedicator Of Cytokinesis 2 (DOCK2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166509
tested applications
WB, SDS-PAGE

Description

Dedicator Of Cytokinesis 2 Protein is a recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Dedicator Of Cytokinesis 2 (DOCK2)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 31.7 kDa  Observed MW (SDS-PAGE): 32 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Ile390-Glu635
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q92608
Alias
DOCK2, IMD40, Dock2, dedicator of cytokinesis 2
Background
Protein DOCK2
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

DOCK2 is a hematopoietic-specific GEF expressed in leukocytes, activating Rac1/Rac2 to control chemotaxis and immune cell migration. It regulates lymphocyte development, T cell activation, and neutrophil responses to chemokines like CXCL12. DOCK2 interacts with ELMO1 to mediate actin polymerization, essential for leukocyte motility and immune responses. Dysregulation causes defects in lymphocyte trafficking and inflammation. In infections and cancer, DOCK2 can promote or suppress disease progression. Its activity depends on membrane lipids like PIP3 and phosphorylation. Knockout models show immunodeficiency and impaired immune surveillance, emphasizing DOCK2’s role in immunity.

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