Human Dedicator Of Cytokinesis 2 (DOCK2) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein DOCK2
proveedor
Abbexareference
abx166509Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Dedicator Of Cytokinesis 2 Protein is a recombinant Human protein expressed in E. coli.
Background
DOCK2 is a hematopoietic-specific GEF expressed in leukocytes, activating Rac1/Rac2 to control chemotaxis and immune cell migration. It regulates lymphocyte development, T cell activation, and neutrophil responses to chemokines like CXCL12. DOCK2 interacts with ELMO1 to mediate actin polymerization, essential for leukocyte motility and immune responses. Dysregulation causes defects in lymphocyte trafficking and inflammation. In infections and cancer, DOCK2 can promote or suppress disease progression. Its activity depends on membrane lipids like PIP3 and phosphorylation. Knockout models show immunodeficiency and impaired immune surveillance, emphasizing DOCK2’s role in immunity.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Dedicator Of Cytokinesis 2 (DOCK2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 31.7 kDa Observed MW (SDS-PAGE): 32 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ile390-Glu635 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
DOCK2
dry ice
No
availability
Shipped within 5-7 working days.
alias
DOCK2, IMD40, Dock2, dedicator of cytokinesis 2
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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