Human Cytotoxic T-Lymphocyte Protein 4 (CTLA4) Protein
169€ (10 µg)
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935106861
info@markelab.com
name
Human Cytotoxic T-Lymphocyte Protein 4 (CTLA4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx691392
tested applications
SDS-PAGE
Description
Human Cytotoxic T-lymphocyte Protein is a recombinant protein from Human produced in Human Cells. Recombinant Human Cytotoxic T-lymphocyte Protein 4 is produced by our Mammalian expression system and the target gene encoding Lys36-Asp161 is expressed with a Flag tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Cytotoxic T-lymphocyte |
| Host | Human |
| Origin | Human |
| Observed MW | Molecular Weight: 14.5 kDa Sequence Fragment: Lys36-Asp161 Tag: C-terminal Flag tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | PBS, pH7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | P16410 |
| Alias | Cytotoxic T-lymphocyte protein 4,CD,GSE,GRD4,ALPS5,CD152,Cytotoxic T-lymphocyte-associated antigen 4,CTLA-4,IDDM12,CELIAC3, |
| Background | Protein CTLA4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Cytotoxic T-lymphocyte associated protein 4 (CTLA-4), encoded by the CTLA4 gene on chromosome 2, is an essential immune checkpoint receptor primarily expressed on activated T cells and regulatory T cells (Tregs). CTLA-4 plays a crucial role in maintaining immune homeostasis by delivering inhibitory signals to downregulate T cell activation and proliferation. This receptor functions by binding to the ligands CD80 (B7-1) and CD86 (B7-2), which are expressed on antigen-presenting cells (APCs). By inhibiting excessive immune responses, CTLA-4 prevents autoimmunity and maintains immune tolerance to self-antigens. CTLA-4 is the first immune checkpoint to have been targeted for immunotherapy, exemplified by the development of the monoclonal antibody ipilimumab, which blocks CTLA-4 to boost anti-tumor immune responses. Given its significance in regulating immune responses, CTLA-4 is a focus of research in fields ranging from oncology to autoimmune disorders.
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