Human Cytoplasmic Aconitate Hydratase (ACO1) Protein
234€ (1 µg)
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Name
Human Cytoplasmic Aconitate Hydratase (ACO1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx073951
Tested Applications
SDS-PAGE
Description
Aconitase-1 is a recombinant enzyme.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Cytoplasmic Aconitate Hydratase (ACO1) |
| Host | E. coli |
| Assay Type | Activity: Not tested Tag: N-terminal His tag |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques. |
| Size 1 | 1 µg |
| Size 2 | 5 µg |
| Size 3 | 50 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM Tris-HCl (pH 8.0), 2 mM DTT, 100 mM NaCl and 10% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4°C if entire vial will be used within 2-4 weeks. Store at -20 °C for longer periods of time. For long-term storage, it is recommended to add a carrier protein (0.1% HAS or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P21399 |
| Alias | IRP1,ACONS,HEL60,IREB1,IREBP,IREBP1 |
| Background | Protein ACO1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Concentration: 0.5 mg/ml |
Background
Aconitase 1 (ACO1) is a dual-function iron-sulfur protein located in the cytoplasm, acting as both an enzyme and an iron-responsive element-binding protein (IRP1). As an enzyme, ACO1 catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate in the tricarboxylic acid (TCA) cycle, contributing to cellular energy production. Under low iron conditions, ACO1 switches to its role as IRP1, binding to iron-responsive elements (IREs) in mRNAs to regulate the expression of genes involved in iron metabolism, such as ferritin and transferrin receptor. This functional versatility allows ACO1 to coordinate cellular energy metabolism and iron homeostasis. Dysregulation of ACO1 is implicated in disorders related to iron overload or deficiency, as well as oxidative stress-induced damage in neurodegenerative diseases.
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