Human Cyclin Dependent Kinase Inhibitor 1A (CDKN1A) Protein
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
Human Cyclin-Dependent Kinase Inhibitor 1A Protein is a recombinant protein kinases.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Cyclin Dependent Kinase Inhibitor 1A (CDKN1A) |
| Host | E. coli |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Origin | Human |
| Observed MW | Molecular Weight: 20.2 kDa Concentration: 0.5 mg/ml Sequence Fragment: 1-164 AA. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques. |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 100 µg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Buffer | 20 mM Tris-HCl buffer, pH 8.0, 2 M Urea, 0.1 M NaCl and 10% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at 4 °C if the entire vial will be used within 4 weeks. Store at -20 °C for long term storage. For long term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P38936 |
| Background | Protein CDKN1A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Related Products
Human CDKN1A (Cyclin-dependent kinase inhibitor 1) ELISA Kit
Ver Producto
Rat CDKN1A (Cyclin Dependent Kinase Inhibitor 1A) ELISA Kit
Ver Producto
CDKN1A antibody
CDKN1A(p21, CIP1, WAF1) is a cyclin-dependent kinase inhibitor. CDKN1A binds to and inhibits the activity of cyclin-CDK2 or-CDK4 complexes, and thus functions as a regulator of cell cycle progression at the G1 phase. The expression of CDKN1A is induced by wild-type but not mutant p53 protein, through which CDKN1A mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. CDKN1A can interact with proliferating cell nuclear antigen(PCNA), and plays a regulatory role in S phase DNA replication and DNA damage repair. CDKN1A was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Two alternatively spliced variants, which encode an identical protein, have been reported.
Ver Producto