Human Coxsackie And Adenovirus Receptor Like Membrane Protein (CLMP) CLIA Kit

Product specifications

CLIA Kits

Coxsackie And Adenovirus Receptor Like Membrane Protein (CLMP)

Human

Chemiluminescent

Quantitative

Sandwich

0.156 ng/ml - 10 ng/ml

< 0.058 ng/ml

Optimal dilutions/concentrations should be determined by the end user.

96 tests

5 × 96 tests

10 × 96 tests

Lyophilized

CLIA

Serum, plasma, tissue homogenates and other biological fluids.

Shipped within 5-20 working days.

 Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.

No

ACAM,ASAM,CSBM,CSBS,Adipocyte adhesion molecule,Coxsackie- and adenovirus receptor-like membrane protein,CAR-like membrane protein

CLIA Kits CLMP

RUO

The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.   This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

CLMP is a transmembrane protein belonging to the immunoglobulin superfamily and shares structural similarity with the coxsackie and adenovirus receptor (CXADR). CLMP is widely expressed in epithelial and endothelial tissues, where it contributes to tight junction formation and maintenance of cell polarity. It mediates homophilic adhesion and strengthens intercellular junctions, playing a role in epithelial barrier integrity. Mutations in CLMP have been linked to congenital short bowel syndrome, a rare developmental disorder characterized by reduced intestinal length due to impaired embryonic gut elongation. CLMP is thought to regulate cellular signaling pathways that influence proliferation and differentiation during organogenesis. In addition to its developmental roles, CLMP has been implicated in regulating vascular permeability and may contribute to immune cell trafficking in inflammatory conditions. Structurally, CLMP contains extracellular immunoglobulin-like domains that mediate adhesion and intracellular domains that interact with cytoskeletal proteins to stabilize cell-cell junctions. Dysregulation of CLMP expression has been observed in certain cancers, suggesting a potential role in tumor progression and metastasis. Current research focuses on understanding its signaling mechanisms and exploring its therapeutic potential in tissue repair and developmental disorders.

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