Human Complement C4a anaphylatoxin (C4a) Protein

Este producto es parte de Complement C4B (Chido/Rodgers blood group)
Human Complement C4a anaphylatoxin (C4a) Protein

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935106861

info@markelab.com

Precio

234€ (10 µg)

Protein C4B

proveedor

Abbexa

reference

abx166851

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Complement Fragment C4a (C4a) Protein is a recombinant Human protein expressed in E. coli.


Background

C4B is a component of the classical and lectin pathways of the complement system, which plays an essential role in immune defense by promoting pathogen clearance, inflammation, and immune complex removal C4B is involved in the formation of the C3 convertase complex, which activates the complement cascade and results in the destruction of pathogens via opsonization and lysis It also participates in the regulation of immune responses and plays a role in clearing immune complexes that could otherwise contribute to tissue damage C4B is implicated in the Chido/Rodgers blood group system, which is used in transfusion medicine C4B deficiency or dysfunction is associated with autoimmune diseases, including systemic lupus erythematosus, where excessive complement activation exacerbates tissue damage The balance of C4B in the complement system is crucial for maintaining immune homeostasis and preventing chronic inflammation

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Complement Fragment C4a (C4a)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 12.5 kDa Observed MW (SDS-PAGE): 13 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Asn680-Arg756 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

C4B


dry ice

No


availability

Shipped within 5-7 working days.


alias

CH,C4F,CO4,C4B1,C4B2,C4B3,C4B5,C4BD,C4B12,C4B_2,CPAMD3,Basic complement C4,C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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