Human Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra) Protein

Product specifications

Proteins and Peptides

Colony Stimulating Factor 2 Receptor Alpha (CSF2Ra)

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 42.3 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Arg28-Pro112
Tag: N-terminal His tag and GST tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

P15509

Granulocyte-macrophage colony-stimulating factor receptor subunit alpha,GMR,CD116,CSF2R,SMDP4,CDw116,CSF2RX,CSF2RY,GMCSFR,CSF2RAX,CSF2RAY,alphaGMR,GMR-alpha,GMCSFR-alpha,GM-CSF-R-alpha

Protein CSF2RA

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Colony stimulating factor 2 receptor subunit alpha (CSF2RA) is a protein that serves as part of the receptor complex for granulocyte-macrophage colony-stimulating factor (GM-CSF), a cytokine critical for the growth, differentiation, and function of granulocytes and macrophages. This receptor subunit is primarily expressed on the surface of myeloid lineage cells, including neutrophils, monocytes, and macrophages, as well as on some non-hematopoietic tissues. CSF2RA forms a heterodimer with the common beta chain (CSF2RB) to mediate the signaling of GM-CSF, which activates pathways such as JAK/STAT, MAPK, and PI3K, driving cell proliferation, survival, and activation. Dysregulation of CSF2RA signaling has been associated with conditions like inflammatory diseases, including rheumatoid arthritis and asthma, as well as hematological malignancies such as leukemia. Mutations or deletions in the CSF2RA gene can impair immune responses and are linked to congenital disorders like surfactant metabolism dysfunction in the lung. Given its role in immune modulation, CSF2RA is being explored as a therapeutic target in cancer immunotherapy and inflammatory conditions, aiming to modulate the activity of GM-CSF and its downstream effects. Understanding its molecular mechanisms continues to provide insights into immune regulation and potential clinical interventions.

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