Human C-C Chemokine Receptor Type 2 (CCR2) Protein

Product specifications

Proteins and Peptides

C-C Chemokine Receptor Type 2 (CCR2)

E. coli

Human

Unconjugated

Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Please enquire.
Tag: N-terminal His tag

Recombinant

> 90%

1 mg

5 mg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.

Shipped within 1-2 months.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

CCR2,MCP-1 receptor,CC CKR2,CKR2,CD192,CCR2A,CCR2B,chemokine receptor CCR2,chemokine (C-C motif) receptor 2,CCR-2,CKR2A,CKR2B,CMKBR2,MCP-1-R,CC-CKR-2

Protein CCR2

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

C-C Chemokine Receptor Type 2 (CCR2) is a critical G-protein-coupled receptor (GPCR) that binds C-C chemokines, primarily CCL2 (MCP-1) and related ligands such as CCL7 and CCL8. CCR2 is expressed on monocytes, macrophages, T cells, and dendritic cells, playing a central role in monocyte recruitment to sites of inflammation and tissue damage. Upon binding its ligands, CCR2 triggers intracellular signaling pathways such as MAPK, JAK/STAT, and PI3K, leading to cell activation, chemotaxis, and cytokine production. CCR2 and its ligand CCL2 are vital in the immune response to infections, promoting pathogen clearance, but their dysregulation is implicated in various inflammatory diseases, including atherosclerosis, rheumatoid arthritis, obesity, and chronic kidney disease. In cancer, CCR2 contributes to tumor progression by recruiting tumor-associated macrophages (TAMs), which promote angiogenesis, immune suppression, and metastasis. Targeting CCR2 has emerged as a promising strategy for modulating inflammatory responses and treating cancers, with CCR2 antagonists in development for conditions like fibrosis, autoimmunity, and tumor microenvironment modulation. Research into CCR2 signaling continues to elucidate its role in monocyte biology, chronic inflammation, and immune regulation, positioning it as a key therapeutic target for inflammatory diseases and cancer therapies.

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