Human Cell Death Inducing DFFA Like Effector A (CIDEA) Protein
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Description
Cell Death Inducing DFFA Like Effector A Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Cell Death Inducing DFFA Like Effector A (CIDEA) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 57.1 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Gly219 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O60543 |
| Alias | CIDE-A, cell death-inducing DFFA-like effector a, cell death inducing DFFA like effector a,CIDEA |
| Background | Protein CIDEA |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CIDEA is a lipid droplet-associated protein involved in regulating lipid metabolism and energy homeostasis. It promotes lipid droplet fusion and inhibits lipolysis by modulating the activity of key enzymes such as adipose triglyceride lipase (ATGL). CIDEA is highly expressed in brown adipose tissue, where it contributes to thermogenesis and energy expenditure. Beyond its metabolic functions, CIDEA also plays a role in apoptosis, where it interacts with caspase-activated DNAse to mediate DNA fragmentation. Dysregulation of CIDEA is associated with obesity, insulin resistance, and non-alcoholic fatty liver disease. Research on CIDEA focuses on its dual roles in lipid metabolism and apoptosis, offering potential therapeutic targets for metabolic disorders and cancer.
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