Human CD97 Antigen (ADGRE5) Protein (Active)

Este producto es parte de ADGRE - Adhesion G protein-coupled receptor E
Product Graph
1079€ (100 µg)

Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.

935106861
info@markelab.com
name
Human CD97 Antigen (ADGRE5) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691684
tested applications
SDS-PAGE

Description

Human CD97 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the first 398 amino acids (Met 1-Gln 398) of human CD97 isoform 2 (NP_001775.2) extracellular domain was fused with a polyhistidine tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
CD97
Host
HEK293 cells
Origin
Human
Observed MW
Molecular Weight: 42.6 kDa
Sequence Fragment: Met1-Gln398
Tag: C-terminal His tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 85% (SDS-PAGE)
Size 1
100 µg
Form
 
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_001775.2
Alias
ADGRE5,CD97,BL-Ac (F2),CD97,TM7LN1
Background
Protein ADGRE5
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Adhesion G protein-coupled receptor E5 (ADGRE5), also known as CD97, is a member of the adhesion GPCR family and plays an essential role in cell-cell and cell-matrix interactions. ADGRE5 is highly expressed in immune cells, including macrophages, neutrophils, and T-cells, as well as in endothelial and epithelial cells, where it mediates adhesion, migration, and cellular activation. It is a heterodimeric receptor that interacts with extracellular matrix proteins and cellular ligands such as CD55 (decay-accelerating factor), enabling immune surveillance and inflammation regulation. ADGRE5 is upregulated during inflammation, infection, and cancer progression, contributing to leukocyte recruitment, angiogenesis, and metastasis. Dysregulation of ADGRE5 is associated with autoimmune diseases, such as rheumatoid arthritis and inflammatory bowel disease, and its expression levels are linked to tumor aggressiveness in cancers like glioblastoma and colorectal cancer. Therapeutic targeting of ADGRE5 is being explored as a strategy to modulate immune responses and inhibit tumor metastasis by disrupting its signaling pathways and ligand interactions.

Related Products

EH7229

Human CD97 (CD97 antigen) ELISA Kit

Ver Producto
ER0820

Rat CD97 (Cluster of Differentiation 97) ELISA Kit

Ver Producto
FNab01510

ADGRE5 antibody

This gene encodes a member of the EGF-TM7 subfamily of adhesion G protein-coupled receptors, which mediate cell-cell interactions. These proteins are cleaved by self-catalytic proteolysis into a large extracellular subunit and seven-span transmembrane subunit, which associate at the cell surface as a receptor complex. The encoded protein may play a role in cell adhesion as well as leukocyte recruitment, activation and migration, and contains multiple extracellular EGF-like repeats which mediate binding to chondroitin sulfate and the cell surface complement regulatory protein CD55. Expression of this gene may play a role in the progression of several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms with 3 to 5 EGF-like repeats have been observed for this gene. This gene is found in a cluster with other EGF-TM7 genes on the short arm of chromosome 19.

Ver Producto