Human CD180 Antigen (CD180) Protein (Active)
923€ (50 µg)
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935106861
info@markelab.com
name
Human CD180 Antigen (CD180) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691822
tested applications
SDS-PAGE
Description
Human CD180 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human CD180 (NP_005573.2) extracellular domain (Met 1-Gly 626) was fused with a polyhistidine tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CD180 |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 69 kDa Sequence Fragment: Met1-Gly626 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 92% (SDS-PAGE) |
| Size 1 | 50 µg |
| Size 2 | 500 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NP_005573.2 |
| Alias | LY64,Ly78,RP105,Lymphocyte antigen 64,Radioprotective 105 kDa protein |
| Background | Protein CD180 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD180, also known as RP105 (radioprotective 105 kDa protein), is a cell surface molecule prominently expressed on immune cells, particularly B cells, macrophages, and dendritic cells. As a member of the Toll-like receptor (TLR) family, CD180 plays a significant role in the immune system by recognizing microbial components and activating immune responses. Although structurally similar to TLRs, CD180 functions distinctly by forming complexes with other receptors rather than directly recognizing pathogen-associated molecular patterns (PAMPs). Its primary function is to regulate B cell activation, proliferation, and differentiation, which is crucial for antibody production and adaptive immunity. CD180 is a regulatory receptor that modulates the response of B cells to various antigens, providing an essential checkpoint in immune activation to avoid excessive immune responses and maintain balance.
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