Human CD180 Antigen (CD180) Protein (Active)

Este producto es parte de CD180 - CD180 molecule
Product Graph
923€ (50 µg)

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935106861
info@markelab.com
name
Human CD180 Antigen (CD180) Protein (Active)
category
Proteins and Peptides
provider
Abbexa
reference
abx691822
tested applications
SDS-PAGE

Description

Human CD180 Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human CD180 (NP_005573.2) extracellular domain (Met 1-Gly 626) was fused with a polyhistidine tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
CD180
Host
HEK293 cells
Origin
Human
Observed MW
Molecular Weight: 69 kDa
Sequence Fragment: Met1-Gly626
Tag: C-terminal His tag
Validity: The validity for this protein is 12 months.
Expression
Recombinant
Purity
> 92% (SDS-PAGE)
Size 1
50 µg
Size 2
500 µg
Form
 
Tested Applications
SDS-PAGE
Buffer
Lyophilized from sterile PBS, pH 7.4.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
NCBI Accession
NP_005573.2
Alias
LY64,Ly78,RP105,Lymphocyte antigen 64,Radioprotective 105 kDa protein
Background
Protein CD180
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

CD180, also known as RP105 (radioprotective 105 kDa protein), is a cell surface molecule prominently expressed on immune cells, particularly B cells, macrophages, and dendritic cells. As a member of the Toll-like receptor (TLR) family, CD180 plays a significant role in the immune system by recognizing microbial components and activating immune responses. Although structurally similar to TLRs, CD180 functions distinctly by forming complexes with other receptors rather than directly recognizing pathogen-associated molecular patterns (PAMPs). Its primary function is to regulate B cell activation, proliferation, and differentiation, which is crucial for antibody production and adaptive immunity. CD180 is a regulatory receptor that modulates the response of B cells to various antigens, providing an essential checkpoint in immune activation to avoid excessive immune responses and maintain balance.

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