Human CD160 Antigen (CD160) Protein
481€ (20 µg)
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name
Human CD160 Antigen (CD160) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694135
tested applications
SDS-PAGE
Description
Human CD160 Antigen (CD160) Protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 14.9 kDa Observed MW (SDS-PAGE): 25 kDa Sequence Fragment: Met1-Leu158 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | >90% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute in sterile H2O. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. |
| Dry Ice | No |
| UniProt ID | O95971 |
| Gene ID | 11126 |
| OMIM | 64463 |
| Alias | NK1,BY55,NK28,Natural killer cell receptor BY55 |
| Background | Protein CD160 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
The CD160 molecule, encoded by the CD160 gene, is a glycoprotein primarily expressed on the surface of cytotoxic lymphocytes, including natural killer (NK) cells, NKT cells, a subset of CD8+ T cells, and certain peripheral blood T-cell populations. CD160 was first identified for its unique expression pattern on immune cells and its role in modulating cytotoxic activity, playing a critical role in immune response against tumors and infected cells. CD160 functions as a receptor that binds to a variety of ligands, notably major histocompatibility complex (MHC) class I molecules and herpesvirus entry mediator (HVEM), both of which have implications in immune activation and inhibition. CD160 serves as an immune checkpoint, similar to other co-inhibitory receptors such as CTLA-4 and PD-1, and its signaling is implicated in modulating immune responses. Its functions in immune surveillance and regulation make it particularly significant in oncology, viral immunology, and autoimmune disorders. CD160 is also characterized by its restricted expression on peripheral blood monocytes and on cells in the gastrointestinal tract, indicating its broader role in tissue-specific immune responses and homeostasis.
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