Human CASP2 And RIPK1 Domain Containing Adaptor With Death Domain (CRADD) Protein
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Description
Human CRADD Protein is a recombinant protein from Human produced in E. coli. A DNA sequence encoding the human CRADD (P78560) (Met 1-Glu 199) was fused with a polyhistidine tag at the C-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CRADD |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 24.1 kDa Sequence Fragment: Met1-Glu199 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, 20% glycerol, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P78560 |
| Alias | RAIDD, MRT34,CASP2,RIPK1,CRADD |
| Background | Protein CRADD |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Death domain-containing protein CRADD, also known as RIP, is involved in mediating cellular responses to stress, particularly in the regulation of apoptosis. It contains a death domain (DD) and serves as a key adaptor protein in the signaling pathways triggered by death receptors. CRADD is known to participate in the formation of the death-inducing signaling complex (DISC) when activated by signals such as tumor necrosis factor (TNF) or Fas ligand (FasL), leading to the activation of caspases and subsequent apoptosis. In addition, CRADD has been implicated in other processes, such as inflammation and neurodegeneration. Its expression and function are tightly regulated and have been linked to both cell survival and death in different contexts.
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