Human Death Domain-Containing Protein Cradd (CRADD) Protein
1235€ (100 µg)
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Name
Human Death Domain-Containing Protein Cradd (CRADD) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx692373
Tested Applications
SDS-PAGE
Description
Death Domain-Containing Protein Cradd (CRADD) protein is a recombinant Human protein expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Death Domain-Containing Protein Cradd (CRADD) |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: Met1-Glu199 Tag: C-terminal His tag |
| Origin | Human |
| Observed MW | 24.1 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: Sterile PBS, 20% glycerol, pH 8.0. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | P78560 |
| Alias | RAIDD, MRT34,CASP2,RIPK1,CRADD |
| Background | Protein CRADD |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
Death domain-containing protein CRADD, also known as RIP, is involved in mediating cellular responses to stress, particularly in the regulation of apoptosis. It contains a death domain (DD) and serves as a key adaptor protein in the signaling pathways triggered by death receptors. CRADD is known to participate in the formation of the death-inducing signaling complex (DISC) when activated by signals such as tumor necrosis factor (TNF) or Fas ligand (FasL), leading to the activation of caspases and subsequent apoptosis. In addition, CRADD has been implicated in other processes, such as inflammation and neurodegeneration. Its expression and function are tightly regulated and have been linked to both cell survival and death in different contexts.
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