Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) Protein
4303€ (1 mg)
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935106861
info@markelab.com
name
Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx655572
tested applications
WB, SDS-PAGE
Description
Human Carcinoembryonic Antigen (CEA) Protein (Active) is an Active Recombinant Human protein expressed in 293F cells for use in cell culture and activity assays.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 (CEACAM5) |
| Host | 293F cell |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 73 kDa Observed MW (SDS-PAGE): 80 kDa Concentration: Prior to lyophilization: 350 µg/ml Sequence Fragment: Lys35-Ala685 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 98% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 10 mM PBS, pH 7.6, containing 5% Trehalose. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06731 |
| Gene ID | 1048 |
| Alias | CEA,CD66eMeconium antigen 100,Carcinoembryonic antigen |
| Background | Protein CEACAM5 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CEACAM5, also known as carcinoembryonic antigen (CEA), is a glycoprotein member of the immunoglobulin superfamily that plays a prominent role in cell adhesion, immune modulation, and intercellular signaling. It is highly expressed in epithelial tissues and is overexpressed in various cancers, including colorectal, pancreatic, and lung cancers, where it is used as a tumor marker for diagnosis, prognosis, and monitoring therapeutic responses. CEACAM5 mediates homophilic and heterophilic adhesion, influencing cellular aggregation, invasion, and metastasis. It interacts with other CEACAM family members and cell surface receptors to regulate signaling pathways involved in cell proliferation, migration, and immune evasion. Structurally, CEACAM5 contains multiple immunoglobulin-like domains, a glycosylphosphatidylinositol (GPI) anchor, and extensive glycosylation sites that contribute to its functional diversity. In cancer, CEACAM5 promotes tumor progression by enhancing adhesion to extracellular matrix components and modulating immune responses, such as inhibiting T-cell activation. Therapeutic strategies targeting CEACAM5, including monoclonal antibodies and vaccines, are under development to exploit its role as a biomarker and driver of tumor progression. CEACAM5 also plays roles in physiological processes like epithelial cell polarity and tissue homeostasis, reflecting its multifaceted importance.
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