Human CAMPATH-1 Antigen (CD52) Protein
1716€ (1 mg)
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935106861
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name
Human CAMPATH-1 Antigen (CD52) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx652965
tested applications
WB, SDS-PAGE
Description
Human Cluster Of Differentiation 52 (CD52) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | CAMPATH-1 Antigen (CD52) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Please enquire. Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 1 mg |
| Size 2 | 5 mg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 1-2 months. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | HE5,CDW52,EDDM5,CAMPATH-1 antigen,Cambridge pathology 1,Epididymal secretory protein E5,Human epididymis-specific protein 5 |
| Background | Protein CD52 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD52 is a small glycoprotein predominantly expressed on the surface of mature lymphocytes (both T and B cells), monocytes, macrophages, eosinophils, and some epithelial cells of the reproductive system. The CD52 molecule plays an important role in regulating immune cell function, and its high expression on lymphocytes makes it a valuable therapeutic target in immunology and oncology, particularly in treatments for autoimmune diseases and certain types of leukemia, such as chronic lymphocytic leukemia (CLL). The precise function of CD52 remains somewhat unclear, although it is believed to be involved in modulating immune responses and cellular interactions. CD52 is the target of the monoclonal antibody alemtuzumab, a treatment used in autoimmune conditions like multiple sclerosis (MS) and certain cancers like CLL. Alemtuzumab binds to CD52 on the surface of immune cells and triggers their destruction through immune-mediated mechanisms, leading to immunosuppression. This therapeutic aspect has drawn attention to the biological and clinical significance of the CD52 molecule.
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