Human Calcium Sensing Receptor (CASR) ELISA Kit

Este producto es parte de CASR - Calcium Sensing Receptor
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585€ (96 tests)

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935106861
info@markelab.com
name
Human Calcium Sensing Receptor (CASR) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx251069
tested applications
ELISA

Description

Human Calcium Sensing Receptor ELISA Kit is an ELISA Kit against Calcium Sensing Receptor.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
ELISA Kits
Immunogen Target
Calcium Sensing Receptor (CASR)
Reactivity
Human
Detection Method
Colorimetric
Assay Data
Quantitative
Assay Type
Sandwich
Test Range
0.78 ng/ml - 50 ng/ml
Sensitivity
0.47 ng/ml
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Size 1
96 tests
Size 2
5 × 96 tests
Size 3
10 × 96 tests
Form
Lyophilized
Tested Applications
ELISA
Sample Type
Tissue homogenates, cell lysates and other biological fluids.
Availability
Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
Storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
Dry Ice
No
UniProt ID
P41180
Alias
CASR,CAR,EIG8,FHH,FIH,GPRC2A,HHC,HHC1,HYPOC1,NSHPT,PCAR1,hCasR
Background
Elisa kits for CASR
Status
RUO
Note
Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request.
This product is for research use only.   The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments.   Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.

Descripción

Calcium Sensing Receptor (CASR) is a G-protein-coupled receptor (GPCR) that plays a central role in maintaining systemic calcium homeostasis. CASR is primarily expressed in the parathyroid glands, kidneys, and bone, where it detects minute changes in extracellular calcium levels. Activation of CASR in the parathyroid glands leads to the inhibition of parathyroid hormone (PTH) secretion, a key regulator of calcium and phosphate balance. This prevents excessive calcium resorption from bone and calcium reabsorption in the kidneys, helping to maintain optimal calcium concentrations. CASR signaling in the renal tubules enhances calcium excretion and regulates water balance, contributing to fluid and electrolyte homeostasis. Beyond calcium regulation, CASR influences processes such as bone remodeling, insulin secretion, and vascular smooth muscle tone, playing critical roles in skeletal, metabolic, and cardiovascular health. Mutations in the CASR gene are linked to disorders such as familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism (NSHPT), conditions characterized by dysregulated calcium sensing and metabolism. CASR is also implicated in diseases like chronic kidney disease (CKD), where calcium-phosphate imbalances are common, and in cancers such as breast cancer, where CASR promotes tumor cell growth and metastasis to bones. Therapeutically, CASR modulators like calcimimetics are used to treat secondary hyperparathyroidism and hypercalcemia in conditions such as primary hyperparathyroidism. Research into CASR signaling continues to reveal its broader roles in inflammation, cell proliferation, and immune response, highlighting its importance as a potential therapeutic target for metabolic and bone disorders.

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